Thyroid peroxidase antibodies in dried blood specimens of newborns.
Thyroid peroxidase antibodies in dried blood specimens of newborns.
复制标题
新生儿干血标本中的甲状腺过氧化物酶抗体。
DOI：
10.1089/105072502320288474
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
C. A. Larson
中科院分区：
文献类型：
--
作者：
M. Mitchell;R. Hermos;C. A. Larson
Previous studies have disclosed that a substantial percentage of infants from mothers with thyroid autoimmunity have antibodies to thyroid peroxidase (TPOAb) at birth. Furthermore, these antibodies have been shown to be of maternal origin. In view of this we thought it would be of interest to determine the prevalence of TPOAb in newborns from an unselected population of women. This was done by retrieving stored dried blood specimens from 240 full-term healthy infants, which had been obtained during 1999 for routine newborn screening. Ten percent of the randomly selected specimens tested TPOAb positive. Thyroid function in the mothers could not be evaluated because all specimens had been tested anonymously. In summary, our results indicate that a significant percentage of newborns were TPOAb positive. It is unclear at this time whether such antibodies reflected maternal thyroid autoimmunity and/or other autoimmune disorders. However, the close association between autoimmune thyroid disease and TPOAb positivity raises the possibility of abnormal thyroid function in some of the mothers.
