Randomized, placebo-controlled double blind study on the efficacy of influenza immunization on absenteeism of health care workers
Randomized, placebo-controlled double blind study on the efficacy of influenza immunization on absenteeism of health care workers
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DOI：
10.1097/00006454-199909000-00007
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发表时间：
1999-09-01
影响因子：
3.6
通讯作者：
Virtanen, M
中科院分区：
文献类型：
--
作者：
Saxén, H;Virtanen, M
背景在健康的成年人中，流感免疫减少了呼吸道感染引起的缺勤，但关于其在卫生保健工作者中的有效性的数据很少。确定常规灭活甲型流感疫苗对减少儿科医护人员因呼吸道感染而缺勤的影响。研究设计。1996 ~ 1997年冬季在两所儿科医院进行了一项随机、安慰剂对照、双盲的疫苗效力研究。主要终点是因呼吸道感染而从医院损失的工作天数。缺勤记录基于个人疾病日志。结果，在547名随机接种疫苗的人中，427人（78%）完成了4个月的随访并返回了疾病日志。免疫接种未能减少呼吸道感染的发作（接种者为1.8次/研究期，对照组为2.0次）。同样，疫苗未能影响接种者患呼吸道感染的总天数（分别为13.5天和14.6天）。然而，由于呼吸道感染而损失的工作天数（分别为1.0天和1.4天，P = 0.02），特别是研究人员在上班或下班时感到自己无法工作的总天数（2.5天和3.5天，P 0.02）显著减少。流感疫苗接种减少了28%与呼吸道感染有关的缺勤。因此，我们认为，应建议在儿科环境中工作的卫生保健提供者进行常规的年度流感免疫接种。
Background. In healthy adults influenza immunization reduces absenteeism caused by respiratory infections, but data on its efficacy among health care workers are scarce.Objective. To determine the effect of the conventional inactivated influenza A vaccine on reducing absenteeism related to respiratory infections among pediatric health care providers.Study design. A randomized, placebo-controlled, double blind study on vaccine efficacy was conducted in two pediatric hospitals during the winter season 1996 to 1997, The primary endpoint was days of work lost from the hospital because of respiratory infections. The documentation of absenteeism was based on personal sickness logs.Results, Of the 547 randomized vaccinees 427 (78%) persons completed the 4-month follow-up and returned the sickness logs. Immunization failed to reduce episodes of respiratory infections (1.8 episodes/study period among vaccinees vs. 2.0 among controls). Similarly the vaccine failed to affect the total number of days the vaccinees suffered from respiratory infections (13.5 days vs. 14.6 days, respectively). However, days of work lost because of respiratory infections (1.0 days vs. 1.4 days, respectively, P = 0.02) and especially total numbers of days the study persons felt themselves unable to work when either on or off duty (2.5 days vs, 3.5 days, P 0.02) were significantly decreased.Conclusion. Influenza vaccination reduced absenteeism related to respiratory infections by 28%. We therefore believe that routine annual influenza immunizations should be recommended to health care providers working in pediatric settings.