Recombinant interleukin-2 directly augments the cytotoxicity of human monocytes
Recombinant interleukin-2 directly augments the cytotoxicity of human monocytes
复制标题
重组白细胞介素 2 直接增强人单核细胞的细胞毒性
作者：
M. Malkovsky;B. Loveland;M. North;G. Asherson;Liquan Gao;P. Ward;W. Fiers
白介素2(IL-2)最初被描述为T细胞在体外持续增殖所需的生长因子1，2是一种已知结构的糖蛋白激素，在活体4中似乎对免疫反应的产生具有重要作用。除了T淋巴细胞，B淋巴细胞5和具有自然杀伤活性的大颗粒淋巴细胞(NK细胞)6也能对IL-2产生反应。然而，IL-2的作用似乎仅限于淋巴细胞，因此使用了术语“T淋巴细胞营养激素”7。我们提供的证据表明，作为对人重组IL-2的直接和快速反应，人单核细胞显示出显著增强的细胞毒活性，而不是对人重组糖基化干扰素-γ(干扰素-γ)或脂多糖的反应。我们的结果揭示了IL-2以前未知的功能，并提示它可能参与单核细胞-T细胞的相互作用。
Interleukin-2 (IL-2), originally described as a growth factor required for sustained proliferation of T cells in vitro1,2 is a glycoprotein hormone of known structure3 which appears to be important for the generation of immune responses in vivo4. As well as T lymphocytes, B lymphocytes5 and large granular lymphocytes with natural killer activity (NK cells)6 can also respond to IL-2. The action of IL-2 seemed to be limited specifically to lymphocytes, however, and the term 'T-lymphocytotrophic hormone' was used7. Here we provide evidence that human monocytes display a substantially increased cytotoxic activity as a direct and rapid response to human recombinant IL-2 but not to human recombinant glycosylated interferon-γ (IFN-γ) or lipopolysac-charide. Our results reveal a previously unknown function of IL-2 and suggest its possible involvement in monocyte-T cell interactions.
白介素 2 激活的细胞毒性细胞对自体人淋巴细胞的破坏。
DOI：
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发表时间：
1986
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Sondel,PM;Hank,JA;Kohler,PC;Chen,BP;Minkoff,DZ;Molenda,JA
通讯作者：
Molenda,JA