Balancing autoaggressive and protective T cell responses
Balancing autoaggressive and protective T cell responses
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DOI：
10.1016/j.jaut.2007.02.002
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发表时间：
2007-03-01
影响因子：
12.8
通讯作者：
Knoechel, Birgit
中科院分区：
文献类型：
--
作者：
Abbas, Abul K.;Lohr, Jens;Knoechel, Birgit
激活和抑制信号之间的精细协调平衡是免疫系统有效攻击和消除病原微生物而不对抗自身抗原的能力的基础。这种平衡的紊乱是自身免疫性疾病发病机制的基础。相反，阐明这种平衡的机制可能为操纵它提供合理的策略，以提高疫苗和肿瘤免疫治疗的疗效。精确调控最清晰的例证之一是效应T细胞和调节性T细胞的产生。为了分析这种调节的机制，我们开发了一种转基因小鼠模型，其中单个群体的T细胞在体内对其已知的同源抗原发生反应。在这里，我们用这个实验模型总结了我们的研究，说明了T细胞反应的序列，并试图剖析控制这些反应的刺激。(C) 2007 Elsevier Ltd.版权所有。
A finely orchestrated balance between activating and inhibitory signals is fundamental for the ability of the immune system to effectively attack and eliminate pathogenic microbes but to not react against self-antigens. Derangements of this balance underlie the pathogenesis of autoimmune diseases. Conversely, elucidating the mechanisms of this balance may provide rational strategies for manipulating it in order to enhance the efficacy of vaccines and tumor immunotherapy. One of the clearest illustrations of precise regulation is in the generation of effector and regulatory T cells. In order to analyze the mechanisms of this regulation, we have developed a transgenic mouse model in which a single population of T cells reacts against its known cognate antigen in vivo. Here we summarize our studies with this experimental model, illustrating the sequence of T cell responses that develop and attempting to dissect the stimuli that control these responses. (C) 2007 Elsevier Ltd. All rights reserved.