HIV Capsid Assembly, Mechanism, and Structure
HIV Capsid Assembly, Mechanism, and Structure
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DOI：
10.1021/acs.biochem.6b00159
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发表时间：
2016-05-10
期刊：
影响因子：
2.9
通讯作者：
Chen, Bo
中科院分区：
文献类型：
--
作者：
Chen, Bo
HIV基因组材料被称为衣壳的蛋白质外壳包裹，由类似于1000-1500个衣壳蛋白的拷贝构建。由于其稳定性和完整性对病毒的正常生命周期和感染性至关重要，因此HIV衣壳是一种有前途的抗病毒药物靶标。在本文中，我们回顾的研究塑造我们的理解的结构和动力学的衣壳蛋白和各种形式的组装，以及组装机制。
The HIV genome materials are encaged by a proteinaceous shell called the capsid, constructed from similar to 1000-1500 copies of the capsid proteins. Because its stability and integrity are critical to the normal life cycle and infectivity of the virus, the HIV capsid is a promising antiviral drug target. In this paper, we review the studies shaping our understanding of the structure and dynamics of the capsid proteins and various forms of their assemblies, as well as the assembly mechanism.