Lymph node-induced immune tolerance in chronic lymphocytic leukaemia: a role for caveolin-1
Lymph node-induced immune tolerance in chronic lymphocytic leukaemia: a role for caveolin-1
复制标题
DOI：
10.1111/j.1365-2141.2012.09148.x
复制
发表时间：
2012-07-01
影响因子：
6.5
通讯作者：
Joshi, Shantaram S.
中科院分区：
文献类型：
--
作者：
Gilling, Christine E.;Mittal, Amit K.;Joshi, Shantaram S.
新出现的证据表明，肿瘤微环境（TME）调节慢性淋巴细胞白血病（CLL）的行为。然而，这一过程中涉及的确切机制和分子仍然未知。来自淋巴结（LN）、骨髓（BM）和外周血（PB）的CLL细胞的基因表达谱表明在淋巴结中的CLL细胞（LN-CLL）中致耐受性标签的过表达。基于它们在B细胞生物学、CLL进展或免疫调节中的作用，选择该83个基因标签中的一些基因用于进一步分析。CAV 1（P=0.041）、FGFR 1亚型8（P =0.032）、PTPN 6（P= 0.031）和ZWINT（P
Emerging evidence indicates that the tumour microenvironment (TME) regulates the behaviour of chronic lymphocytic leukaemia (CLL). However, the precise mechanism and molecules involved in this process remain unknown. Gene expression profiles of CLL cells from lymph node (LN), bone marrow (BM) and peripheral blood (PB) indicate overexpression of a tolerogenic signature in CLL cells in lymph nodes (LN-CLL). Based on their role in B cell biology, the progression of CLL, or immune regulation, a few genes of this 83-gene signature were selected for further analyses. We observed a significant correlation between the clinical outcomes and the expression of CAV1 (P=0.041), FGFR1 isoform 8 (P=0.032), PTPN6 (P=0.031) and ZWINT (P