Facilitated Cross-Species Transmission of Prions in Extraneural Tissue
Facilitated Cross-Species Transmission of Prions in Extraneural Tissue
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DOI：
10.1126/science.1215659
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发表时间：
2012-01-27
期刊：
影响因子：
56.9
通讯作者：
Laude, Hubert
中科院分区：
文献类型：
--
作者：
Beringue, Vincent;Herzog, Laetitia;Laude, Hubert
朊病毒是感染性病原体，基本上由PrPSc组成，PrPSc是宿主编码的朊病毒蛋白PrPC的异常折叠形式。PrPSc和PrPC之间的受约束的空间相互作用被认为提供了具有物种特异性的朊病毒，并控制跨物种传播到其他宿主群体，包括人类。我们比较了绵羊和人PrP转基因小鼠的脑和淋巴组织复制外源性、低效传播朊病毒的能力。对于朊病毒，如引起慢性消耗性疾病和牛海绵状脑病的朊病毒，类扁桃体组织始终比大脑更容易感染。此外，当通过脑中的应变转移克服传播障碍时，一种独特的媒介在脾脏中繁殖，脾脏保留了感染原始宿主的能力。因此，朊病毒跨物种传播的效力可以表现出明显的组织依赖性。
Prions are infectious pathogens essentially composed of PrPSc, an abnormally folded form of the host-encoded prion protein PrPC. Constrained steric interactions between PrPSc and PrPC are thought to provide prions with species specificity and to control cross-species transmission into other host populations, including humans. We compared the ability of brain and lymphoid tissues from ovine and human PrP transgenic mice to replicate foreign, inefficiently transmitted prions. Lymphoid tissue was consistently more permissive than the brain to prions such as those causing chronic wasting disease and bovine spongiform encephalopathy. Furthermore, when the transmission barrier was overcome through strain shifting in the brain, a distinct agent propagated in the spleen, which retained the ability to infect the original host. Thus, prion cross-species transmission efficacy can exhibit a marked tissue dependence.