Multifunctional lipid/quantum dot hybrid nanocontainers for controlled targeting of live cells
Multifunctional lipid/quantum dot hybrid nanocontainers for controlled targeting of live cells
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DOI：
10.1002/anie.200600545
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发表时间：
2006-01-01
影响因子：
16.6
通讯作者：
Vogel, Horst
中科院分区：
文献类型：
--
作者：
Gopalakrishnan, Gopakumar;Danelon, Christophe;Vogel, Horst
在这次交流中，我们报告了一个有趣的观察广泛的细胞成像和操纵的潜力：疏水量子点可以很容易地纳入脂质囊泡的双层膜。这种脂质/QD纳米容器混合囊泡能够与活细胞融合，从而用荧光QD选择性地染色细胞的质膜并将囊泡的货物转移到细胞中或转移到活细胞的细胞质中。我们的研究结果表明，细胞和脂质膜可以整合任何类型的疏水纳米颗粒，其大小与膜厚度相匹配，从而为将它们作为个体或与纳米生物技术的广泛应用集成进行操作提供了新的可能性。
In this communication, we report on an interesting observation of wide-ranging potential for cellular imaging and manipulation: Hydrophobic QDs can be easily incorporated into the bilayer membrane of lipid vesicles. Such lipid/QD nanocontainer hybrid vesicles are capable either to fuse with live cells, thereby stain the cell’s plasma membrane selectively with fluorescent QDs and transfer the vesicle’s cargo into the cell or to transfer into the cytoplasm of live cells. Our results imply that cell and lipid membranes can integrate any kind of hydrophobic nanoparticle whose size matches the membrane thickness, opening novel possibilities to manipulate them as individuals or in ensemble with wide-ranging applications for nanobiotechnology.