Trends in head and neck cancer incidence in Denmark, 1978-2007: focus on human papillomavirus associated sites
Trends in head and neck cancer incidence in Denmark, 1978-2007: focus on human papillomavirus associated sites
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DOI：
10.1002/ijc.25699
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发表时间：
2011-08-01
影响因子：
6.4
通讯作者：
Kjaer, Susanne Kruger
中科院分区：
文献类型：
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作者：
Blomberg, Maria;Nielsen, Ann;Kjaer, Susanne Kruger
本研究的目的是评估1978-2007年丹麦男性和女性头颈癌（HNC）发病率的总体趋势，描述HNC在不同解剖部位的分布和发病率，并确定人乳头瘤病毒（HPV）相关癌症的发病率是否正在增加。数据来自全国癌症登记数据库。为了评估HPV感染的可能影响，鳞状细胞癌的部位被分类为HPV相关、潜在HPV相关或HPV无关。总共确定了26 474起事件，整个期间的总发病率有所增加。口腔（每年2.2%）、扁桃体（每年4.8%）、口咽（每年3.5%）和下咽（每年4.4%）肿瘤的发病率显著增加。男性唇癌发病率显著下降（每年-5.0%）。HPV相关部位的癌症（n = 3650）显示发病率显著增加，主要发生在< 60岁的个体中。相反，与HPV感染无关的部位的HNC发生率显著降低（男性）或几乎没有变化（女性）。我们的研究结果表明HPV感染对丹麦HNC的流行病学有显著影响。HPV 16是HNC中最常见的类型;因此，最近引入的HPV疫苗接种可能在未来预防HPV相关的头颈部癌症。
The aim of our study was to assess the overall trends in the incidence of head-and-neck cancer (HNC) among Danish men and women in 1978-2007, to describe the distribution and incidences of HNCs at different anatomical sites, and to determine whether the incidence of human papillomavirus (HPV)-associated cancers is increasing. Data were extracted from the nationwide Cancer Registry database. To assess the possible impact of HPV infection, the sites of squamous cell carcinomas were categorized as HPV-associated, potentially HPV-associated or HPV-unrelated. In total, 26,474 incident cases were identified and the overall incidence increased throughout the period. Significantly increasing incidence rates were notably seen for tumors in the oral cavity (2.2% per year), tonsils (4.8% per year), oropharynx (3.5% per year) and hypopharynx (4.4% per year). A significantly decreasing incidence of lip cancer was observed among men (-5.0% per year). Cancers at HPV-associated sites (n = 3650) showed strongly increasing incidence rates, primarily in individuals < 60 years. In contrast, HNCs at sites not related to HPV infection showed a significant decrease (in men) or virtually no change in incidence (in women). Our results suggest a marked impact of HPV infection on the epidemiology of HNCs in Denmark. HPV16 is the type most often found in HNCs; thus, the recent introduction of vaccination against HPV may in the future prevent HPV-associated cancers of the head and neck.