Structural studies on the R-type lipopolysaccharide of Aeromonas hydrophila
Structural studies on the R-type lipopolysaccharide of Aeromonas hydrophila
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DOI：
10.1016/j.carres.2003.12.008
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发表时间：
2004-03-15
影响因子：
3.1
通讯作者：
Tomás, JM
中科院分区：
文献类型：
--
作者：
Knirel, YA;Vinogradov, E;Tomás, JM
A rough strain of Aeromonas hydrophila, AH-901, has an R-type lipopolysaccharide with the complete core. The following core structure was established by chemical degradations followed by sugar and methylation analyses along with ESIMS and NMR spectroscopy:beta-D-Gal-(1-->4) L-alpha-D-Hep-(1-->6)D-alpha-D-Hep-(1-->6)-D-alpha-D-Hep-(1-->6)-beta-D-Glc-(1-->4)-L-alpha-D-Hep-(1-->5)-alpha-Kdo-(2-->alpha-D-GlcN-(1-->7)-L-alpha-D-Hep-(1-->2)-L-alpha-D-Hep-(1-->3) P-4where D-alpha-D-Hep and L-alpha-D-Hep stand for D-glycero- and L-glycero-alpha-D-manno-heptose, respectively; Kdo stands for 3-deoxy-D-manno-oct-2-ulosonic acid; all monosaccharides are in the pyranose form; the degree of substitution with beta-D-Gal is similar to50%. Lipid A of the lipopolysaccharide has a 1,4'-bisphosphorylated beta-D-GlcN-(I --> 6)-alpha-D-GlcN disaccharide backbone with both phosphate groups substituted with 4-amino-4-deoxyarabinose residues. (C) 2003 Elsevier Ltd. All rights reserved.
