L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells
L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells
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DOI：
10.1038/ni1469
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发表时间：
2007-07-01
影响因子：
30.5
通讯作者：
Sallusto, Federica
中科院分区：
文献类型：
--
作者：
Guarda, Greta;Hons, Miroslav;Sallusto, Federica
缺乏淋巴结归巢受体L-选择素和CCR 7的T淋巴细胞在稳定状态下不会迁移到淋巴结。相反，我们发现淋巴结引流部位的成熟树突状细胞或佐剂接种招募L-选择素阴性的CCR 7（-）效应和记忆CD 8（+）T细胞。这种募集需要CXCR 3在T细胞上表达，并且通过高内皮微静脉与CXCR 3配体CXCL 9的内腔表达一致地发生。在反应性淋巴结中，募集的T细胞与携带抗原的树突状细胞建立稳定的相互作用并杀死它们，限制了这些树突状细胞激活初始CD 4（+）和CD 8（+）T细胞的能力。血液传播的效应T细胞和记忆T细胞向淋巴结的诱导性募集可能代表了终止初次免疫应答和限制二次免疫应答的机制。
T lymphocytes lacking the lymph node-homing receptors L-selectin and CCR7 do not migrate to lymph nodes in the steady state. Instead, we found here that lymph nodes draining sites of mature dendritic cells or adjuvant inoculation recruited L-selectin- negative CCR7(-) effector and memory CD8(+) T cells. This recruitment required CXCR3 expression on T cells and occurred through high endothelial venules in concert with lumenal expression of the CXCR3 ligand CXCL9. In reactive lymph nodes, recruited T cells established stable interactions with and killed antigen-bearing dendritic cells, limiting the ability of these dendritic cells to activate naive CD4(+) and CD8(+) T cells. The inducible recruitment of blood-borne effector and memory T cells to lymph nodes may represent a mechanism for terminating primary and limiting secondary immune responses.