Bromoacetophenone-based photonucleases: photoinduced cleavage of DNA by 4'-bromoacetophenone-pyrrolecarboxamide conjugates.
Bromoacetophenone-based photonucleases: photoinduced cleavage of DNA by 4'-bromoacetophenone-pyrrolecarboxamide conjugates.
复制标题
基于溴苯乙酮的光核酸酶：通过 4-溴苯乙酮-吡咯甲酰胺缀合物光诱导 DNA 裂解。
DOI：
10.1021/ol9903279
复制
发表时间：
1999
期刊：
影响因子：
5.2
通讯作者：
Jeon,R
中科院分区：
文献类型：
--
作者：
Wender,PA;Jeon,R
研究了4′-溴苯乙酮衍生物作为光诱导DNA切割剂的作用。合成了吡咯卡波酰胺偶联的4′-溴苯乙酮类化合物，并测定了它们的DNA切割活性和序列选择性。
4‘-Bromoacetophenone derivatives which upon excitation can generate monophenyl radicals capable of hydrogen atom abstraction were investigated as photoinducible DNA cleaving agents. Pyrrolecarboxamide-conjugated 4‘-bromoacetophenones were synthesized, and their DNA cleaving activities and sequence selectivities were determined.