GANGLIOSIDES IN CEREBROSPINAL-FLUID IN PROBABLE ALZHEIMERS-DISEASE
GANGLIOSIDES IN CEREBROSPINAL-FLUID IN PROBABLE ALZHEIMERS-DISEASE
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DOI：
10.1001/archneur.1991.00530220048018
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发表时间：
1991-10-01
影响因子：
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通讯作者：
SVENNERHOLM, L
中科院分区：
文献类型：
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作者：
BLENNOW, K;DAVIDSSON, P;SVENNERHOLM, L
测定了43例“疑似阿尔茨海默病”患者和19例健康对照者脑脊液中四种主要脑神经节苷脂（gm1、GD1a、GD1b和gt1b）的浓度。阿尔茨海默病分为I型（阿尔茨海默病的特征是记忆障碍和主要的皮层顶叶症状）和II型（一般认知和轻度精神错乱症状，有或没有轻度顶叶症状）。1型阿尔茨海默病患者的GM1浓度显著高于2型阿尔茨海默病患者和年龄匹配的对照组，但2型阿尔茨海默病患者和年龄匹配的对照组之间没有显著差异。由于神经节苷脂在神经细胞膜中富集，尤其是在突触中，研究结果表明，I型阿尔茨海默病患者的皮质神经细胞变性比II型阿尔茨海默病患者更严重。
The concentrations of the four major brain gangliosides-GM1, GD1a, GD1b, and GT1b-were determined in cerebrospinal fluid from 43 patients with "probable Alzheimer's disease" and 19 healthy controls. Alzheimer's disease was divided into type I (with the memory disturbances and predominant cortical parietal symptoms that are characteristic of Alzheimer's disease) and type II (with general cognitive and mild confusional symptoms, with or without only mild parietal symptoms). The GM1 concentration was significantly higher in patients with Alzheimer's disease type I than in those with Alzheimer's disease type II and age-matched controls, but did not differ significantly between patients with Alzheimer's type II and age-matched controls. As gangliosides are enriched in nerve cell membranes, preferentially in synapses, the findings suggest more severe degeneration of cortical nerve cells in patients with Alzheimer's disease type I than in those with Alzheimer's disease type II.