Cutting Edge: Immediate RANTES Secretion by Resting Memory CD8 T Cells Following Antigenic Stimulation 1

Cutting Edge: Immediate RANTES Secretion by Resting Memory CD8 T Cells Following Antigenic Stimulation 1
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尖端技术:抗原刺激后静息记忆 CD8 T 细胞立即分泌 RANTES 1

DOI:
10.4049/jimmunol.170.4.1615
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发表时间:
2003
期刊:
The Journal of Immunology
影响因子:
--
通讯作者:
J. Marvel
J. Marvel
中科院分区:
--
文献类型:
--
作者:
T. Walzer;A. Marçais;F. Saltel;C. Bella;P. Jurdic;J. Marvel

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CD 8记忆应答的效率部分依赖于细胞功能能力的改变。为了鉴定在引发后可以修饰的效应子功能,我们比较了由初始和记忆CD 8 T细胞产生的趋化因子。我们的研究结果表明,与幼稚细胞相比,静息记忆CD 8 T细胞含有高水平的RANTES mRNA。因此,它们具有在离体抗原刺激后快速分泌RANTES的能力。与IFN-γ相反,RANTES分泌主要是由于预先存在的mRNA的翻译。
The efficiency of CD8 memory response relies partially on the modification of cellular functional capacities. To identify effector functions that can be modified following priming, we have compared the chemokines produced by naive and memory CD8 T cells. Our results show that in contrast to naive cells, resting memory CD8 T cells contain high levels of RANTES mRNA. As a result, they have the capacity to rapidly secrete RANTES upon ex vivo antigenic stimulation. In contrast to that of IFN-γ, RANTES secretion is mainly due to the translation of the pre-existing mRNA.
DOI: 10.1016/s1074-7613(00)80642-1
发表时间: 1998-12-01
期刊: IMMUNITY
影响因子: 32.4
作者:
Agarwal, S;Rao, A
通讯作者: Rao, A
初始 T 细胞和记忆 T 细胞之间的质量差异对更快、更有效的记忆 CD8 T 细胞反应做出了重大贡献。
DOI: --
发表时间: 1998
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Kedl,RM;Mescher,MF
通讯作者: Mescher,MF