Systematic review of the economic aspects of nonadherence to antipsychotic medication in patients with schizophrenia.
Systematic review of the economic aspects of nonadherence to antipsychotic medication in patients with schizophrenia.
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DOI：
10.2147/ppa.s41609
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发表时间：
2013
影响因子：
2.2
通讯作者：
Alvarez M
中科院分区：
文献类型：
--
作者：
Dilla T;Ciudad A;Alvarez M
有强有力的证据支持不坚持抗精神病药物与精神分裂症复发之间的联系。然而，不遵守的经济后果就不那么明显了。本文报告的系统性综述评估了不坚持抗精神病药物治疗的经济方面。对PubMed MEDLINE、EMBASE、PENGINFO、BIOSIS和循证医学综述数据库中的科学论文进行了系统的综述。纳入了衡量抗精神病药物依从性的研究，并提供了关于医疗费用的比较信息。8项研究符合纳入标准。所有这些都是观察性的。尽管这些研究在设计、依从性措施和分析的成本构成方面存在差异，但这项系统性综述的结果表明，不坚持抗精神病药物与住院率和资源利用率的增加有关，从而导致直接医疗成本的增加。不坚持抗精神病药物治疗会导致不良的健康和经济结果；因此，作者建议支持旨在提高依从性的干预措施，因为它们可以在不大幅增加成本的情况下改善患者的健康。
There is strong evidence supporting the link between nonadherence to antipsychotic medication and relapse of schizophrenia. However, less obvious are the economic consequences of nonadherence. The systematic review reported here evaluated the economic aspects of nonadherence to antipsychotic medication. A systematic review of scientific papers in the PubMed MEDLINE, Embase, PsychINFO, BIOSIS, and Evidence-Based Medicine Reviews databases was undertaken. Studies that measured adherence to antipsychotic medication and that provided comparative information on health care costs were included. Eight studies met the inclusion criteria. All were observational. Despite the differences between the studies in terms of design, adherence measures, and cost components analyzed, the results of this systematic review indicate that nonadherence to antipsychotic medication is associated with increased hospitalization rates and resource utilization, resulting in increased direct health care costs. Nonadherence to antipsychotic medication results in poor health and economic outcomes; therefore, the authors suggest endorsing interventions aimed at improving adherence because they can improve patient health without substantially increasing costs.