A quantitative trait locus for alcohol consumption in selectively bred rat lines
A quantitative trait locus for alcohol consumption in selectively bred rat lines
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DOI：
10.1097/00000374-199806000-00017
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发表时间：
1998-06-01
影响因子：
3.2
通讯作者：
Li, TK
中科院分区：
文献类型：
--
作者：
Carr, LG;Foroud, T;Li, TK
针对高酒精消耗量和低酒精消耗量的选择性育种导致了酒精偏好（P）和酒精非偏好（NP）大鼠系的建立，这些大鼠系的酒精消耗量存在很大差异。将这些品系进行自交，并产生F2互交后代，以检测影响酒精消耗量的数量性状位点（QTL）。在第4染色体上发现了一个QTL，其最大lod值为8.6，该QTL以加性方式作用，占总表型变异的11%，约占遗传变异的三分之一。神经肽Y是一种内源性抗焦虑药和神经调节剂，已被定位于4号染色体的同一区域。这项研究是基因组分析的一个进展，表明不同的，选择性繁殖的大鼠品系之间的杂交可以用来确定QTL，影响酒精消费的基因的定位可能对人类酒精滥用和酒精中毒的病因学具有重要意义。
Selective breeding for high and low alcohol consumption led to the establishment of alcohol-preferring (P) and alcohol-nonpreferring (NP) rat lines that differ greatly in their alcohol consumption. These lines were inbred and F2 intercross progenies were generated to detect quantitative trait loci (QTLs) influencing alcohol consumption. A QTL on chromosome 4 was identified with a maximum lod score of 8.6, This QTL acts in an additive fashion and accounts for 11% of the total phenotypic variability and approximately one-third of the genetic variability. Neuropeptide Y, an endogenous anxiolytic and neuromodulator, has been mapped to this same region of chromosome 4. This study is an advance in genome analyses, demonstrating that crosses between divergent, selectively bred rat lines can be used to identify QTLs, Localization of a gene influencing alcohol consumption may have important implications for the etiology of alcohol abuse and alcoholism in humans.