Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R
Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R
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DOI：
10.1074/jbc.m005304200
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发表时间：
2000-10-06
影响因子：
4.8
通讯作者：
Gurney, AL
中科院分区：
文献类型：
--
作者：
Xie, MH;Aggarwal, S;Gurney, AL
我们报告了一种新型人类细胞因子的鉴定，它与白细胞介素 (IL)-10 有远亲关系，我们将其称为 IL-22，IL-22 是由活化的 T 细胞产生的。 IL-22 是 CRF2-4 的配体，CRF2-4 是 II 类细胞因子受体家族的成员。尽管据报道该受体可作为 IL-10 信号传导的第二个成分，但尚未报道该受体的高亲和力配体。干扰素受体家族的新成员，我们称之为 IL-22R，与 CRF2-4 一起作为第二个成分来启用 IL-22 信号传导。 IL-22 不结合 IL-10R，确定细胞系通过激活 STAT 1、3 和 5 对 IL-22 做出反应，但对 IL-10 无反应。与 IL-10 相比，IL-22 不会抑制单核细胞响应 LPS 产生促炎细胞因子，也不会影响单核细胞上的 IL-10 功能，但对 Th2 T 产生 IL-4 具有适度的抑制作用细胞。
We report the identification of a novel human cytokine, distantly related to interleukin (IL)-10, which we term IL-22, IL-22 is produced by activated T cells. IL-22 is a ligand for CRF2-4, a member of the class II cytokine receptor family. No high affinity ligand has yet been reported for this receptor, although it has been reported to serve as a second component in IL-10 signaling, A new member of the interferon receptor family, which we term IL-22R, functions as a second component together with CRF2-4 to enable IL-22 signaling. IL-22 does not bind the IL-10R, Cell lines were identified that respond to IL-22 by activation of STATs 1, 3, and 5, but were unresponsive to IL-10, In contrast to IL-10, IL-22 does not inhibit the production of proinflammatory cytokines by monocytes in response to LPS nor does it impact IL-10 function on monocytes, but it has modest inhibitory effects on IL-4 production from Th2 T cells.