Transformation of fibroblast-like synoviocytes in rheumatoid arthritis; from a friend to foe.
Transformation of fibroblast-like synoviocytes in rheumatoid arthritis; from a friend to foe.
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类风湿性关节炎中成纤维细胞样滑膜细胞的转化：从朋友到敌人。
DOI：
10.1186/s13317-020-00145-x
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发表时间：
2021-02-05
期刊：
影响因子：
--
通讯作者：
Mahmoudi M
中科院分区：
文献类型：
--
作者：
Mousavi MJ;Karami J;Aslani S;Tahmasebi MN;Vaziri AS;Jamshidi A;Farhadi E;Mahmoudi M
关节软骨的肿胀和进行性破坏是类风湿性关节炎（RA）的主要特征，类风湿性关节炎是一种系统性自身免疫性疾病，其直接影响滑膜关节，并且通常导致受影响位置的严重残疾。最近的研究表明，B型滑膜细胞（又称成纤维细胞样滑膜细胞（FLS））作为最常见和最主要的常驻细胞，通过产生多种介质在疾病的早期发病和进展中起着至关重要的作用。在RA的发病过程中，FLS的表型发生改变，并表现出与在肿瘤条件下观察到的相似的侵袭行为。FLS改变的应激微环境导致其他免疫细胞的募集，最终形成血管翳。RA FLS的发生与糖、脂、氧代谢途径的显著改变有关，近年来发现RA FLS的遗传异常和表观遗传学改变与其类癌行为有关。在这篇综述中，我们将重点关注的机制，在类风湿关节炎的FLS转化为癌样表型。全面了解这些机制可能会导致设计更有效和有针对性的治疗策略。
Swelling and the progressive destruction of articular cartilage are major characteristics of rheumatoid arthritis (RA), a systemic autoimmune disease that directly affects the synovial joints and often causes severe disability in the affected positions. Recent studies have shown that type B synoviocytes, which are also called fibroblast-like synoviocytes (FLSs), as the most commonly and chiefly resident cells, play a crucial role in early-onset and disease progression by producing various mediators. During the pathogenesis of RA, the FLSs’ phenotype is altered, and represent invasive behavior similar to that observed in tumor conditions. Modified and stressful microenvironment by FLSs leads to the recruitment of other immune cells and, eventually, pannus formation. The origins of this cancerous phenotype stem fundamentally from the significant metabolic changes in glucose, lipids, and oxygen metabolism pathways. Moreover, the genetic abnormalities and epigenetic alterations have recently been implicated in cancer-like behaviors of RA FLSs. In this review, we will focus on the mechanisms underlying the transformation of FLSs to a cancer-like phenotype during RA. A comprehensive understanding of these mechanisms may lead to devising more effective and targeted treatment strategies.
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