ANTIBODY FORMATION - STIMULATION BY POLYADENYLIC AND POLYCYTIDYLIC ACIDS
ANTIBODY FORMATION - STIMULATION BY POLYADENYLIC AND POLYCYTIDYLIC ACIDS
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DOI：
10.1126/science.157.3790.819
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发表时间：
1967-01-01
期刊：
影响因子：
56.9
通讯作者：
NAKANO, M
中科院分区：
文献类型：
--
作者：
BRAUN, W;NAKANO, M
在用绵羊红细胞或其他部分抗原免疫的小鼠中，多聚腺苷和多尿酸或多胞酸和甲基化牛血清白蛋白的络合物可提高抗体形成脾细胞数量的早期增长率。多腺苷和多胞酸似乎分别是关键刺激物的来源，正如细菌中的其他人所证明的那样，这些刺激物可能通过影响核苷酸激酶的活性而发挥作用。激动素核苷和sRNA中的一种腺苷衍生物可拮抗受刺激的抗体反应，但不是正常反应。
Complexes of polyadenylic and polyuridylic acids, or of polycytidylic acid and methylated bovine serum albumin, enhance the early rate of increase in numbers of antibody-forming spleen cells in mice immunized with sheep red blood cells or other partlculate antigens. Polyadenylic and polycytidylic acids, respectively, appear to be the source of the critical stimulators which, as demonstrated by others in bacteria, may act by influencing nucleo-tide kinase activity. The stimulated antibody response, but not the normal response, is antagonized by kinetin riboside and by an adenosine derivative occurring in sRNA.