Histone modification profiles characterize function-specific gene regulation
Histone modification profiles characterize function-specific gene regulation
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DOI：
10.1016/j.jtbi.2012.06.009
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发表时间：
2012-10-07
影响因子：
2
通讯作者：
Kim, Dongsup
中科院分区：
文献类型：
--
作者：
Jung, Inkyung;Kim, Dongsup
染色质修饰在基因调控中普遍存在。尽管付出了很多努力，但仍需要进行系统的研究，以了解每个修饰是否具有取决于其相关基因功能的独特性质。在这里，我们表明，考虑功能特异性组蛋白修饰概况是重要的基因表达水平的准确预测，并保持跨细胞类型。性能改善被认为源于修饰与每种生物学功能的基因表达水平之间的关联。组蛋白修饰和基因表达水平之间的变化关系可以部分解释考虑功能特异性PolII招募机制，并支持更准确的预测PolII occupancy与功能特异性修饰配置文件。我们认为，转录因子和染色质调节因子的功能特异性结合可以解释类似的基因调控机制，如功能特异性PolII招聘，在每个功能基因集。我们的研究表明，每个组蛋白修饰具有不同的特点，根据其相关基因的功能，因此，不同的组蛋白修饰组合的特点功能特异性基因调控。目前的分析可在我们的网络服务器（biodb.kaist.ac.kr/impohis）上获得。(c)2012爱思唯尔有限公司保留所有权利。
Chromatin modification is ubiquitous in gene regulation. Despite much effort, a systematic investigation is needed to understand whether each modification has a unique property depending on the function of its associated genes. Here, we show that consideration of function-specific histone modification profiles is important for accurate prediction of gene expression levels, and is maintained across cell types. The performance improvement is thought to originate from the association between modifications and gene expression levels for each biological function. The varying relationship between histone modifications and gene expression levels can be partly explained by considering function-specific PolII recruitment mechanisms, and is supported by more accurate predictions of PolII occupancies with function-specific modification profiles. We suggest that the function-specific binding of transcription factors and chromatin regulators may explain similar gene regulatory mechanisms, such as function-specific PolII recruitment, in each functional gene set. Our study demonstrates that each histone modification has a different characteristic according to the function of its associated genes; thus, different combinations of histone modification profiles characterize function-specific gene regulation. The current analysis is available on our web server (biodb.kaist.ac.kr/impohis). (c) 2012 Elsevier Ltd. All rights reserved.