Cytological features of myxoid adrenocortical adenoma with a pseudoglandular component: A case report with differential diagnostic considerations
Cytological features of myxoid adrenocortical adenoma with a pseudoglandular component: A case report with differential diagnostic considerations
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具有假腺体成分的粘液样肾上腺皮质腺瘤的细胞学特征：具有鉴别诊断考虑的病例报告
DOI：
10.1002/dc.20854
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发表时间：
2008
影响因子：
1.3
通讯作者：
H. Okabe
中科院分区：
文献类型：
--
作者：
M. Ishida;Keiko Yoshida;K. Miyamoto;M. Iwai;Y. Miyahira;R. Kushima;H. Okabe
粘液样肾上腺皮质肿瘤是极其罕见的肿瘤，文献中仅报道了九种腺瘤和十一种癌。它们偶尔有类似于肾上腺转移性粘液腺癌的假腺体成分。然而，这种不寻常肿瘤的细胞学特征此前尚未被描述过。我们在这里报告了第一个具有假腺成分的粘液样肾上腺皮质腺瘤的细胞病理学研究，特别有助于与转移性粘液腺癌的鉴别诊断。区分粘液样肾上腺皮质腺瘤和肾上腺转移性粘液性腺癌的两个主要细胞病理学特征是：（1）粘液样物质仅存在于细胞外空间，而不存在于细胞质中； (2)细胞核通常位于细胞质的中央部分，而不被压缩到外围。仔细观察这些细胞学特征以及对 Melan A、α-抑制素和突触素的阳性免疫反应性可以得出正确的诊断。诊断。细胞病理醇。 2008年； 36：576-580。 © 2008 Wiley-Liss, Inc.
Myxoid adrenocortical tumors are extremely rare neoplasms with only nine adenomas and eleven carcinomas reported in the literature. They occasionally have a pseudoglandular component resembling metastatic mucinous adenocarcinoma in the adrenal gland. However the cytological features of this unusual tumor have not been previously described. We report here the first cytopathological study of a myxoid adrenocortical adenoma with a pseudoglandular component, contributing especially to the differential diagnosis from metastatic mucinous adenocarcinoma. Two major cytopathological features distinguishing myxoid adrenocortical adenoma from metastatic mucinous adenocarcinoma in the adrenal gland are: (1) the myxoid material is found only in the extracellular space, and not in the cytoplasm; and (2) nuclei are usually located in the central portion of the cytoplasm, and not compressed to the periphery. Careful observation of these cytological features and positive immunoreactivity to Melan A, alpha‐inhibin and synaptophysin can lead to the correct diagnosis. Diagn. Cytopathol. 2008; 36: 576–580. © 2008 Wiley‐Liss, Inc.