Dry eye syndrome in diabetic children
Dry eye syndrome in diabetic children
复制标题
DOI：
10.1177/112067210701700601
复制
发表时间：
2007-11-01
影响因子：
1.7
通讯作者：
Aycan, Z.
中科院分区：
文献类型：
--
作者：
Akinci, A.;Cetinkaya, E.;Aycan, Z.
目的。目的比较1型糖尿病(T1 DM)患者和对照组干眼综合征(DES)的症状、体征和客观检查结果。方法：对104例T1 DM儿童和104例年龄、性别匹配的对照组的DES症状、体征和客观检查结果进行比较。观察T1 DM组的病程、糖尿病视网膜病变、平均血红蛋白A1c水平、青春期状态和伴有自身免疫性疾病的病史。采用方差分析、多元回归分析、t检验、Mann-Whitney U检验和卡方检验进行统计学分析。结果：共有15.4%的糖尿病儿童有干眼症状，而对照组为1.9%(p=0.029)。糖尿病儿童干眼症的发生率为7.7%，而对照组为0.96%(p=0.034)。T1 DM组泪液破裂时间(TBUT)和Schirmer试验结果均显著低于对照组(p=0.018，p=0.024)。总共有7.7%的糖尿病儿童被确诊为DES，0.96%的儿童可能被诊断为DES，而对照组中没有一人被诊断为DES(p=0.03)。T1 DM病程10年以上患者的TT和Schirmer试验结果显著低于正常对照组(P
PURPOSE. To compare the symptoms, signs, and results of objective tests for dry eye syndrome (DES) in type 1 diabetes mellitus (T1DM) patients and controls.METHODS. A total of 104 children with T1DM and 104 age-and sex-matched controls were compared in terms of the symptoms, signs, and results of objective tests for DES. Duration of T1DM, presence of diabetic retinopathy, mean hemoglobin A1c level, pubertal status, and a history of accompanying autoimmune disease were noted in T1DM group. Analysis of variance, multivariate regression analysis, Student t, Mann-Whitney U, and chi-square tests were used for statistical analysis.RESULTS. A total of 15.4% of diabetic children complained of dry eye symptoms, versus 1.9% of the controls (p=0.029). Dry eye signs were detected in 7.7% of diabetic children, versus 0.96% of controls (p=0.034). Tear break-up time (TBUT) and Schirmer test results were significantly lower in T1DM group than controls (p=0.018, p=0.024, respectively). A total of 7.7% of diabetic children had definite and 0.96% had probable diagnosis of DES, versus none of the controls (p=0.03). TBUT and Schirmer test results were significantly lower in patients with more than 10 years duration of T1DM (p