Serum erythropoietin concentration in chronic renal failure: relationship to degree of anemia and excretory renal function.
Serum erythropoietin concentration in chronic renal failure: relationship to degree of anemia and excretory renal function.
复制标题
慢性肾功能衰竭的血清促红细胞生成素浓度：与贫血程度和排泄肾功能的关系。
作者：
H. Radtke;A. Claussner;P. Erbes;E. Scheuermann;W. Schoeppe;K. Koch
采用胎鼠肝细胞法测定了135例慢性肾功能衰竭患者和59例健康人血清促红细胞生成素（SEp）浓度。在肌酐清除率（CCr）范围为2 - 40 ml/min/1.73 sq m的患者中，发现内分泌肾功能与排泄肾功能平行恶化。已知的SEp和红细胞压积（Hct）之间的负相关性不明显，可能是因为肾质量的损失伴随着贫血和肾功能不全的进展。相反，在残余排泄肾功能变化最小的患者中，如在短时间内反复研究的个体患者中，Hct的变化总是伴随着相应SEp浓度的相反变化。因此，慢性肾功能衰竭患者在Hct和SEp之间存在持续的调节反馈机制，该机制可能在较低水平上起作用。
By use of the fetal mouse liver cell assay, serum erythropoietin (SEp) concentration was measured in 135 patients at various stages of chronic renal failure and in 59 healthy subjects. In patients with creatinine clearances (CCr) ranging from 2 to 40 ml/min/1.73 sq m, endocrine renal function was found to deteriorate in parallel to excretory renal function. The known negative correlation between SEp and hematocrit (Hct) was not apparent, probably because of the loss of renal mass accompanying progress of anemia and renal insufficiency. In contrast, in patients with minimal variation of residual excretory renal function, as in individual patients investigated repeatedly within a short period of time, changes of Hct were always accompanied by opposite changes of corresponding SEp concentrations. Thus, patients with chronic renal failure have a sustained regulatory feedback mechanism between Hct and SEp, which probably works at a lower level.