Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components
Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components
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DOI：
10.1016/j.mtcomm.2020.101692
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发表时间：
2020-12-01
影响因子：
3.8
通讯作者：
Kevadiya, Bhavesh D.
中科院分区：
文献类型：
--
作者：
Augustine, Robin;Hasan, Anwarul;Kevadiya, Bhavesh D.
纳米材料在生物和医学领域的应用正在迅速发展，特别是在传统诊断和治疗方法成效有限的领域。纳米材料在生物医学植入物、伤口敷料和药物输送系统等医疗产品中的成功依赖于它们在细胞外基质、细胞和细胞内组分之间的有效相互作用。在与哺乳动物细胞接触时，纳米颗粒（NP）开始与细胞外基质、细胞膜、细胞质蛋白、细胞核和其他细胞器相互作用，这导致纳米颗粒内化和随后的细胞应答。在细胞和分子水平上，由于细胞-纳米材料相互作用而引起的哺乳动物细胞的这种反应主要由纳米材料本身的形态、化学和表面特征决定。本文综述了纳米材料的化学性质、尺寸、形状、表面电荷、形貌、硬度和功能特征等不同属性对细胞-纳米材料相互作用的影响。
The utilization of nanomaterials in the biological and medical field is quickly progressing, particularly in areas where traditional diagnostics and treatment approaches have limited success. The success of nanomaterials in medical products such as biomedical implants, wound dressings and drug delivery systems rely upon their effective interaction between the extracellular matrix, cells, and intracellular components. Upon contact with mammalian cells, nanoparticles (NPs) begin to interact with the extracellular matrix, cell membrane, cytoplasmic proteins, nucleus, and other cellular organelles, which result in nanoparticle internalization and subsequent cellular responses. Such responses elicited by the mammalian cells as a result of the cell-nanomaterials interactions, both at the cellular and molecular level, are mainly determined by the morphological, chemical, and surface characteristics of the nanomaterials themselves. This review provides an overview of how such different attributes, such as chemical nature, size, shape, surface charge, topography, stiffness, and functional features of nanomaterials, influence the cell-nanomaterials interactions.