Reflex cardiovascular and ventilatory responses to increasing H+ activity in cat hindlimb muscle.
Reflex cardiovascular and ventilatory responses to increasing H+ activity in cat hindlimb muscle.
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反射性心血管和通气反应对猫后肢肌肉 H 活性的增加。
DOI：
10.1152/jappl.1989.67.1.256
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Kaufman,MP
中科院分区：
文献类型：
--
作者：
Rotto,DM;Stebbins,CL;Kaufman,MP
静态运动增加动脉压、心率和通气，这些作用被认为部分是由工作肌肉的代谢刺激反射而产生的。在被麻醉的猫身上，我们验证了一种假设，即在动脉内注射乳酸和盐酸，会在肌肉中产生类似于收缩时所见的这些物质的水平，从而反射性地增强心血管和呼吸功能。盐酸（32和57 mM， 1 ml）注入肱三头肌动脉供应使肌内pH值从7.26 +/- 0.05降至7.17 +/- 0.05 (P < 0.01)，反反射性升高动脉压（23 +/- 7 mmHg, P < 0.01）、心率（11 +/- 2次/min， P < 0.001）和通气量（187 +/- 72 ml/min, P < 0.05）。肱三头肌表面静态收缩使肌内pH值从7.28 +/- 0.06降至7.13 +/- 0.06 （P < 0.01）。乳酸比等摩尔盐酸更能引起反射。例如，含有4mm乳酸和0.87 mM H+的乳酸反射性增加了动脉压、心率和通气，而含有0.87 mM HCl的乳酸则没有。中性pH下的动脉内乳酸钠（13和33 mM）对这些变量没有影响。我们的结论是，收缩诱导的H+积累，特别是由乳酸引起的H+积累，可能提供代谢刺激来唤起反射性自主神经效应。
Static exercise increases arterial pressure, heart rate, and ventilation, effects which are believed in part to arise reflexly from a metabolic stimulus in the working muscle. In anesthetized cats, we tested the hypothesis that intra-arterial injections of lactic and hydrochloric acid, which created levels of these substances in muscle similar to those seen during contraction, reflexly increased cardiovascular and ventilatory function. Hydrochloric acid (32 and 57 mM; 1 ml) injected into the arterial supply of the triceps surae decreased intramuscular pH from 7.26 +/- 0.05 to 7.17 +/- 0.05 (P less than 0.01) and reflexly increased arterial pressure (23 +/- 7 mmHg; P less than 0.01), heart rate (11 +/- 2 beats/min; P less than 0.001), and ventilation (187 +/- 72 ml/min; P less than 0.05). Static contraction of the triceps surae decreased intramuscular pH from 7.28 +/- 0.06 to 7.13 +/- 0.06 (P less than 0.01). Lactic acid was more potent in causing reflexes than was equimolar HCl. For example, lactic acid containing 4 mM lactate and 0.87 mM H+ reflexly increased arterial pressure, heart rate, and ventilation, whereas 0.87 mM HCl did not. Intra-arterial sodium lactate (13 and 33 mM) at a neutral pH had no effect on these variables. We conclude that contraction-induced accumulation of H+, especially that arising from lactic acid, might provide a metabolic stimulus to evoke reflex autonomic effects.