Effect of low-dose niacin on high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol ratio.
Effect of low-dose niacin on high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol ratio.
复制标题
小剂量烟酸对高密度脂蛋白胆固醇和总胆固醇/高密度脂蛋白胆固醇比值的影响。
DOI：
10.1001/archinte.1988.00380110121025
复制
发表时间：
1988
影响因子：
--
通讯作者：
M. Luria
中科院分区：
文献类型：
--
作者：
M. Luria
烟酸显着改变血脂浓度，但它的使用已受到限制，因为临床上令人不安的副作用。为了克服这些缺点，55例心血管疾病患者接受了低剂量长效烟酸治疗，1 g/d。治疗持续平均6.7个月，并将血脂值与未治疗组的17例患者进行比较，平均随访6.3个月。未治疗组的血脂值未发生变化。在烟酸治疗组总胆固醇和甘油三酯水平也没有显着变化。高密度脂蛋白（HDL）胆固醇水平从1.01 +/-0.31 mmol/L升高31%至1.32 +/-0.31 mmol/L，总胆固醇/HDL胆固醇比值从6.4 +/-1.9降低27%至4.7 +/-1.3。尽管有这些结果，40%的患者主要是因为副作用而离开研究。除了一名患者出现明显的糖尿病，与烟酸的关系可疑外，没有患者出现严重的副作用，如黄疸或消化性溃疡，如高剂量的药物所见。尽管烟酸，特别是低剂量的烟酸，通常难以施用于患者，但值得考虑作为特别用于升高HDL胆固醇水平和改变总胆固醇/HDL胆固醇比率的廉价药剂。
Niacin significantly alters blood lipid concentrations but its use has been limited because of clinically disturbing side effects. In an attempt to circumvent these drawbacks, 55 patients with cardiovascular disease were given low-dose long-acting niacin, 1 g/d. Treatment was continued for a mean of 6.7 months and lipid values were compared with a non-treated group of 17 patients followed for a mean of 6.3 months. Lipid values did not change in the nontreated group. In the niacin-treated group total cholesterol and triglyceride levels also did not significantly change. High-density lipoprotein (HDL) cholesterol level rose 31% from 1.01 +/- 0.31 mmol/L to 1.32 +/- 0.31 mmol/L and total cholesterol/HDL cholesterol ratio was reduced 27% from 6.4 +/- 1.9 to 4.7 +/- 1.3. Despite these results, 40% of the patients left the study mainly because of side effects. Apart from one patient who developed overt diabetes, of questionable relationship to niacin, no patient developed serious side effects such as jaundice or peptic ulcer as seen with much higher doses of the drug. Although often difficult to administer to patients, niacin, particularly in low dose, deserves consideration as an inexpensive agent especially useful for elevating HDL cholesterol level and altering the total cholesterol/HDL cholesterol ratio.