Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors.
Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors.
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DOI：
10.1093/nar/gkv1118
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发表时间：
2016-01-04
影响因子：
14.9
通讯作者：
Finn R
中科院分区：
文献类型：
--
作者：
Rawlings ND;Barrett AJ;Finn R
MEROPS数据库(http://merops.sanger.ac.uk))是与生物学、医学和生物技术密切相关的多肽酶及其底物和抑制物的综合信息来源。数据库的层次分类如下：同源序列集合被分组为蛋白质物种；蛋白质物种被分组为家族；家族被分组为家族。每个蛋白质物种(称为“正模式”)、家族和家族都有一个类型示例，每个蛋白质物种、家族和家族都有自己的唯一识别符。已经创建了展示多肽酶和多肽酶抑制剂在生物途径中的参与的页面。每一页都显示了参与该途径的肽酶和肽酶抑制剂，以及已知的底物切割和肽酶-抑制剂相互作用，以及与KEGG生物途径数据库的链接。还与IUPHAR药理学指南建立了联系。已经建立了一项新的服务，允许提交已确定的底物裂解，以便可以评估裂解位点的保存。这应该有助于确定一个裂解位点是否在生理上是相关的，因为这种裂解位点很可能是保守的。
The MEROPS database (http://merops.sanger.ac.uk) is an integrated source of information about peptidases, their substrates and inhibitors, which are of great relevance to biology, medicine and biotechnology. The hierarchical classification of the database is as follows: homologous sets of sequences are grouped into a protein species; protein species are grouped into a family; families are grouped into clans. There is a type example for each protein species (known as a ‘holotype’), family and clan, and each protein species, family and clan has its own unique identifier. Pages to show the involvement of peptidases and peptidase inhibitors in biological pathways have been created. Each page shows the peptidases and peptidase inhibitors involved in the pathway, along with the known substrate cleavages and peptidase-inhibitor interactions, and a link to the KEGG database of biological pathways. Links have also been established with the IUPHAR Guide to Pharmacology. A new service has been set up to allow the submission of identified substrate cleavages so that conservation of the cleavage site can be assessed. This should help establish whether or not a cleavage site is physiologically relevant on the basis that such a cleavage site is likely to be conserved.