Assessing the benefits of direct isolation processes
Assessing the benefits of direct isolation processes
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DOI：
10.1021/op034165e
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发表时间：
2004-03-01
影响因子：
3.4
通讯作者：
Anderson, NG
中科院分区：
文献类型：
--
作者：
Anderson, NG
直接分离工艺通常用于中试工厂和制造操作。直接分离工艺相对于使用常规萃取后处理和结晶的工艺的主要益处是由于减少的处理时间而降低的商品成本（COG）。直接分离方法可能是有益的，甚至当产率比来自常规萃取后处理和结晶的产率低5-15%时。扩大直接分离和提取过程的成本可以通过数学模型计算，并且可以评估原材料、劳动力和废物处理的比例成本。虽然直接分离工艺通常比萃取工艺更经济，但直接分离选项并不适用于所有策略。一个角度是提供了一个关于何时开发一个直接的分离过程中提取后处理和结晶过程。
Direct isolation processes are often used in pilot-plant and manufacturing operations. The primary benefit of a direct isolation process over a process using a conventional extractive workup and crystallization is the decreased cost of goods (COG) due to decreased processing time. Direct isolation processes may be beneficial even when the yield is 5-15% below the yield from a conventional extractive workup and crystallization. The costs of scaling up both direct isolation and extraction processes can be calculated by a mathematical model, and the proportional costs of raw materials, labor, and waste disposal can be assessed. Although direct isolation processes are generally more economical than extraction processes, the direct isolation option is not suitable for all strategies. A perspective is offered on when to develop a direct isolation process over an extractive workup and crystallization process.