Effects of neurotensin on hypothalamic and pituitary hormone secretion.
Effects of neurotensin on hypothalamic and pituitary hormone secretion.
复制标题
神经降压素对下丘脑和垂体激素分泌的影响。
DOI：
10.1111/j.1749-6632.1982.tb31568.x
复制
发表时间：
1982
影响因子：
5.2
通讯作者：
Thominet,J
中科院分区：
文献类型：
--
作者：
Frohman,LA;Maeda,K;Berelowitz,M;Szabo,M;Thominet,J
Neurotensin is a tridecapeptide originally isolated from bovine hypothalamus' and subsequently found to have a widespread distribution within the central nervous system (CNS) and in selected areas of the gastrointestinal tract. Among the earliest reports of the effects of neurotensin on endocrine function were its actions on the anterior pituitary2a3 and the pancreatic islets!.'In our initial studies on the endocrine pancreas, it was apparent that the route of administration was of critical importance since cerebroventricular, in contrast to systemic, injection of the peptide did not affect levels of plasma glucagon, insulin, or glucose. 5 We therefore initiated a series of studies to determine whether the pituitary hormone-releasing effects of neurotensin involved central or peripheral mechanisms and to explore the possible mediating role of other centrally active compounds. This report summarizes the experience from our laboratory related to the effects of neurotensin on growth hormone (GH), thyroid-stimulating hormone (TSH), and prolactin (PRL) release and on the mechanism of its action.
