Size-controlled clustering of iron oxide nanoparticles within fluorescent nanogels using LCST-driven self-assembly.
Size-controlled clustering of iron oxide nanoparticles within fluorescent nanogels using LCST-driven self-assembly.
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DOI：
10.1039/c9tb02868d
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发表时间：
2020-05
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通讯作者：
Turgay Yildirim;Md Firoz Pervez;Bo Li;R. O’Reilly
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作者：
Turgay Yildirim;Md Firoz Pervez;Bo Li;R. O’Reilly
利用较低的临界溶液温度(LCST)驱动接枝聚合物在荧光聚合物纳米凝胶上的自组装和交联，实现了氧化铁纳米颗粒在荧光聚合物纳米凝胶中的尺寸可控聚集。接枝聚合物由低聚乙二醇甲基丙烯酸酯(OEGMA)和一种新型的二氯马来酰亚胺功能甲基丙烯酸酯单体组成。由于OEGMA的温度响应行为，当加热到聚合物的LCST以上时，聚合物接枝的IONPs聚集形成更大的纳米聚集体。当这些纳米聚集体通过胺-二氯马来酰亚胺反应进行交联时，就可以制备出定义良好的荧光杂化纳米凝胶。此外，通过改变聚合物在水中接枝IONPs的初始浓度，有效地控制了这些杂化纳米凝胶的尺寸。
Size-controlled clustering of iron oxide nanoparticles (IONPs) within the fluorescent polymer nanogels was achieved using the lower critical solution temperature (LCST) driven self-assembly and cross-linking of grafted polymer on the IONPs. The grafted polymer was comprised of oligoethyleneglycol methacrylate (OEGMA) and a novel dichloromaleimide functional methacrylate monomer as building blocks. As a result of the temperature responsive behavior of OEGMA, polymer grafted IONPs clustered to form larger nano-sized aggregates when heated above the LCST of the polymer. When these nano-sized aggregates were cross-linked using an amine-dichloromaleimide reaction, well-defined fluorescent hybrid nanogels could be fabricated. Moreover, the size of these hybrid nanogels was effectively controlled by varying the initial concentration of the polymer grafted IONPs in water.