Dietary Habits in Japanese Patients with Alopecia Areata.
Dietary Habits in Japanese Patients with Alopecia Areata.
复制标题
DOI：
10.2147/ccid.s335440
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Kanda N
中科院分区：
文献类型：
--
作者：
Hagino T;Okazaki S;Serizawa N;Suzuki K;Kaga M;Otsuka Y;Mikami E;Hoashi T;Saeki H;Matsuda H;Mitsui H;Kanda N
斑秃（AA）的特点是无疤痕，斑片状脱发引起的自身免疫反应，生长期毛囊。AA的发病机制可能受饮食的影响。然而，AA患者的饮食习惯尚未得到精确的检查。因此，本研究的目的是调查AA患者的饮食习惯与健康对照组相比。我们评估了70例成人日本AA患者的饮食习惯，使用的是一种自填式饮食史问卷，并将其与年龄和性别匹配的健康对照组的饮食习惯进行了比较。与对照组相比，日本AA患者的体重指数（BMI）较高，维生素C和水果的摄入量也较高。Logistic回归分析显示AA与BMI相关。视黄醇摄入量与脱发严重程度工具（SALT）评分呈正相关，线性回归分析显示视黄醇摄入量是SALT评分的预测因子。中重度AA患者（即SALT评分> 25）的视黄醇摄入量高于轻度AA患者（SALT评分≤ 25）。患有特应性皮炎（AD）的AA患者的平均年龄低于不患有AD的AA患者;然而，这两组之间的营养素或食物摄入量没有差异。Logistic回归分析显示，年龄与合并AD呈负相关。AA与高BMI相关，高视黄醇摄入是SALT评分的预测因子。应进行进一步的研究，以澄清是否饮食干预，以减少体重指数或限制视黄醇的摄入量可以改变AA的发展或严重程度。
Alopecia areata (AA) is characterized by non-scarring, patchy hair loss caused by autoimmune reactions to anagen hair follicles. The pathogenesis of AA may be affected by the diet. However, the dietary habits of patients with AA have not been precisely examined. Therefore, the aim of this study was to investigate the dietary habits of patients with AA in comparison to those of healthy controls. We evaluated the dietary habits of 70 adult Japanese patients with AA using a brief-type self-administered diet history questionnaire and compared them to the habits of age- and sex-matched healthy controls. Japanese patients with AA had a higher body mass index (BMI) and higher intakes of vitamin C and fruit than the controls. Logistic regression analysis showed that AA was associated with BMI. Retinol intake was positively correlated with severity of alopecia tool (SALT) score, and linear regression analysis revealed that retinol intake was a predictor of SALT score. Retinol intake among patients with moderate to severe AA (ie, a SALT score >25) was higher than that in patients with mild AA (a SALT score ≤25). The mean age of AA patients with atopic dermatitis (AD) was lower than that of AA patients without AD; however, there were no differences in nutrient or food intake between these two groups. Logistic regression analysis showed that the comorbidity AD was negatively associated with age. AA was associated with a high BMI, and high retinol intake was a predictor of SALT score. Further studies should be conducted to clarify whether dietary intervention to reduce BMI or limit retinol intake can alter the development or severity of AA.