AUTORADIOGRAPHIC LOCALIZATION OF GAMMA-AMINOBUTYRIC ACIDA RECEPTORS WITHIN THE VENTRAL TEGMENTAL AREA
AUTORADIOGRAPHIC LOCALIZATION OF GAMMA-AMINOBUTYRIC ACIDA RECEPTORS WITHIN THE VENTRAL TEGMENTAL AREA
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DOI：
10.1007/bf00966870
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发表时间：
1992-01-01
影响因子：
4.4
通讯作者：
KALIVAS, PW
中科院分区：
文献类型：
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作者：
CHURCHILL, L;DILTS, RP;KALIVAS, PW
用兴奋性毒素破坏腹侧被盖区(VTA)的内源性神经元，可使VTA臂旁色素核团和黑质旁核内与GABA(A)受体结合的[H-3]蝇素显著减少(80%)。用6-羟基多巴胺(6-OHDA)选择性损毁多巴胺能神经元并不能减少VTA内[H-3]蝇草酚的结合。然而，多巴胺能神经元的破坏确实使损伤对侧的[H-3]蝇醇结合增加(20%)，这表明对该区域的GABA能神经支配减少。此外，在伏隔内侧注射喹啉酸破坏VTA传入，也不能改变VTA内的[H-3]蝇草酚结合。这些结果与GABA(A)受体主要定位于VTA固有的非多巴胺能神经元是一致的。
Destruction of intrinsic neurons in the ventral tegmental area (VTA) with the excitotoxin, quinolinic acid produced a significant decrease (80%) in [H-3]muscimol binding to GABA(A) receptors within the parabrachial pigmented and paranigral nuclei of the VTA. Selective destruction of the dopaminergic neurons with 6-hydroxydopamine (6-OHDA) did not reduce [H-3]muscimol binding within the VTA. However, the destruction of dopaminergic neurons did produce an increase (20%) in [H-3]muscimol binding contralateral to the lesion, suggesting a reduction in the GABAergic innervation to this region. Additionally, destruction of the VTA afferents with quinolinic acid injections in the medial accumbens failed to produce alterations in [H-3]muscimol binding within the VTA. These results are consistent with the predominant localization of GABA(A) receptors to non-dopaminergic neurons intrinsic to the VTA.