BIOCHEMICAL-COMPARISON OF MAJOR HISTOCOMPATIBILITY COMPLEX-MOLECULES FROM DIFFERENT SUBSPECIES OF MUS-MUSCULUS - EVIDENCE FOR TRANS-SPECIFIC EVOLUTION OF ALLELES
BIOCHEMICAL-COMPARISON OF MAJOR HISTOCOMPATIBILITY COMPLEX-MOLECULES FROM DIFFERENT SUBSPECIES OF MUS-MUSCULUS - EVIDENCE FOR TRANS-SPECIFIC EVOLUTION OF ALLELES
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DOI：
10.1073/pnas.79.7.2342
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
KLEIN, J
中科院分区：
文献类型：
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作者：
ARDEN, B;KLEIN, J
H-2单倍型提取自3个亚种的野生小鼠，M. M. M.tubercus，M. M. molossinus和M. M. castaneus，它们彼此分离了大约1 - 2百万年。通过胰蛋白酶肽图谱比较了由一些多态性H-2位点控制的血清学上不可区分的分子，发现这些图谱是相同的。在野生稻和M. M.大蚊亚种一些H-2等位基因在超过100万年的时间里没有发生改变。H-2基因的这种表观稳定性及其非凡的多态性（每个多态性H-2基因座上约有100个等位基因）可能意味着H-2等位基因的进化就好像它们是独立的基因座。
H-2 haplotypes were extracted from wild mice of 3 subspecies, M. m. domesticus, M. m. molossinus and M. m. castaneus, that were separated from one another for some 1-2 million yr. Serologically indistinguishable molecules controlled by some of the polymorphic H-2 loci were compared by tryptic peptide mapping, and the maps were found to be identical. A number of instances of biochemically indistinguishable H-2 [major histocompatibility complex] molecules were found among wild rice and inbred strains of the M. m. domesticus subspecies. Some of the H-2 alleles have not altered fo for > 1 million yr. This apparent stability of H-2 genes with their extraordinary polymorphism (some 100 alleles at each of the polymorphic H-2 loci), may mean that the H-2 alleles evolve as if they were separate loci.