RAMAN STUDIES ON BRADYKININ AND A CYCLIC BRADYKININ
RAMAN STUDIES ON BRADYKININ AND A CYCLIC BRADYKININ
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DOI：
10.1016/0196-9781(82)90050-x
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发表时间：
1982-01-01
期刊：
影响因子：
3
通讯作者：
STEWART, JM
中科院分区：
文献类型：
--
作者：
FOX, JW;VAVREK, RJ;STEWART, JM
记录了缓激肽在水、氧化氘和固相中的激光拉曼光谱。缓激肽的构象由有序和无序结构组成。这种有序的结构似乎是某种形式的反转。这似乎是有一个在固相的转折结构的增强。还用拉曼光谱检查了含有缓激肽类似物的环状胱氨酸。环状缓激肽类似物给出的拉曼光谱与线性缓激肽非常相似，因此必须与缓激肽具有相似的构象形式。环状缓激肽中的限制性Cys-Cys二硫化物必须用于维持缓激肽受体可接受的构象，因为环状肽表现出生物活性。
Laser Raman spectra of bradykinin in water, deuterium oxide, and the solid phase were recorded. Bradykinin conformation is composed of ordered and unordered structure. The ordered structure appears to be some form of reverse turn. It seems that there is an enhancement of the turn structure in the solid phase. A cyclic cystine containing analog of bradykinin was also examined with Raman spectroscopy. The cyclic bradykinin analog gives a Raman spectrum very similar to that of the linear bradykinin and therefore must share similar conformational forms with bradykinin. The restrictive Cys-Cys disulfide in the cyclic bradykinin must serve to maintain a conformation acceptable to bradykinin receptors since the cyclic peptide exhibits biological activity.