Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells.
Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells.
复制标题
可溶性RAGE阻止1型糖尿病扩展功能性调节性T细胞。
作者：
Type 1 diabetes is an autoimmune disease with no cure, where clinical translation of promising therapeutics has been hampered by the reproducibility crisis. Here, short-term administration of an antagonist to the receptor for advanced glycation end products (sRAGE) protected against murine diabetes at two independent research centers. Treatment with sRAGE increased regulatory T cells (Tregs) within the islets, pancreatic lymph nodes, and spleen, increasing islet insulin expression and function. Diabetes protection was abrogated by Treg depletion and shown to be dependent on antagonizing RAGE with use of knockout mice. Human Tregs treated with a RAGE ligand downregulated genes for suppression, migration, and Treg homeostasis (FOXP3, IL7R, TIGIT, JAK1, STAT3, STAT5b, CCR4). Loss of suppressive function was reversed by sRAGE, where Tregs increased proliferation and suppressed conventional T-cell division, confirming that sRAGE expands functional human Tregs. These results highlight sRAGE as an attractive treatment to prevent diabetes, showing efficacy and reproducibility at multiple research centers and in human T cells.
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影响因子：
7.7
作者：
Coughlan MT;Yap FY;Tong DC;Andrikopoulos S;Gasser A;Thallas-Bonke V;Webster DE;Miyazaki J;Kay TW;Slattery RM;Kaye DM;Drew BG;Kingwell BA;Fourlanos S;Groop PH;Harrison LC;Knip M;Forbes JM
通讯作者：
Forbes JM
影响因子：
8.8
作者：
Das N;Dewan V;Grace PM;Gunn RJ;Tamura R;Tzarum N;Watkins LR;Wilson IA;Yin H
通讯作者：
Yin H
DOI：
10.4049/jimmunol.0903805
发表时间：
2011-03-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Wang Y;Camirand G;Lin Y;Froicu M;Deng S;Shlomchik WD;Lakkis FG;Rothstein DM
通讯作者：
Rothstein DM
影响因子：
8.2
作者：
Forbes, J. M.;Soderlund, J.;Groop, P. -H.
通讯作者：
Groop, P. -H.
影响因子：
3.7
作者：
Laban, Sandra;Suwandi, Jessica S.;Roep, Bart O.
通讯作者：
Roep, Bart O.