Preparation and hemocompatibility of electrospun O-carboxymethyl chitosan/PVA nanofibers
Preparation and hemocompatibility of electrospun O-carboxymethyl chitosan/PVA nanofibers
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DOI：
10.1002/app.43565
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发表时间：
2016-07
影响因子：
3
通讯作者：
Qinghuan Zeng;Jinmin Qin;Xueqiong Yin;Haifang Liu;Li Zhu;Wenyuan Dong;Song Zhang
中科院分区：
文献类型：
--
作者：
Qinghuan Zeng;Jinmin Qin;Xueqiong Yin;Haifang Liu;Li Zhu;Wenyuan Dong;Song Zhang
将壳聚糖脱乙酰化和羧甲基化制备O-羧甲基壳聚糖（CMC），用于静电纺丝。CMC的特征在于使用FTIR，NMR和化学滴定，表明羧甲基化度为51.4%。将CMC与聚乙烯醇（PVA）共纺制备纳米纤维膜。对静电纺丝条件进行了优化。在15.2 g/mL CMC 50 mL、8 g/mL PVA 5 mL、25 kV和23 cm距离的条件下获得的CMC/PVA膜具有直径为70-200 nm的无珠的纳米纤维。在血小板粘附测量之前，用戊二醛交联垫。交联后纳米纤维结构保持不变，但润湿性下降。CMC含量高、微珠少的CMC/PVA复合材料具有较好的血液相容性，血小板粘附率和聚集率均较低。© 2016 Wiley Periodicals，Inc. J.应用聚合物Sci. 2016，133，43565。
Chitosan was deacetylated and carboxymethylated to prepare O-carboxymethyl chitosan (CMC) for further electrospinning. CMC was characterized using FTIR, NMR, and chemical titration, indicating a degree of carboxymethylation of 51.4%. CMC was electrospun together with poly(vinyl alcohol) (PVA) to prepare membranes composed of nanofibers. The electrospinning conditions were optimized. The CMC/PVA membrane obtained at the conditions of 15.2 g/mL CMC 50 mL, 8 g/mL PVA 5 mL, 25 kV, and a distance of 23 cm, had nanofibers without beads, with diameters of 70–200 nm. The mats were crosslinked by glutaraldehyde before platelet adhesion measurement. The nanofibrous structure remained after crosslinking while the wettability decreased. CMC/PVA mats with higher CMC amount and fewer beads, had fewer adherent platelets and less platelets aggregation showing better hemocompatibility. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43565.