IMMUNOGENETIC CONTROL OF EXPERIMENTAL COLLAGEN‐INDUCED ARTHRITIS IN RATS. II. ECIA SUSCEPTIBILITY AND IMMUNE RESPONSE TO TYPE II COLLAGEN (CALF) ARE LINKED TO RT1
IMMUNOGENETIC CONTROL OF EXPERIMENTAL COLLAGEN‐INDUCED ARTHRITIS IN RATS. II. ECIA SUSCEPTIBILITY AND IMMUNE RESPONSE TO TYPE II COLLAGEN (CALF) ARE LINKED TO RT1
复制标题
实验性胶原诱导的大鼠关节炎的免疫遗传学控制 II. ECIA 敏感性和对 II 型胶原 (CALF) 的免疫反应与 RT1 相关。
DOI：
10.1111/j.1744-313x.1981.tb00954.x
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发表时间：
1981
影响因子：
2.2
通讯作者：
C. Dewitt
中科院分区：
文献类型：
--
作者：
M. Griffiths;C. Dewitt
在WF（RTIu/u; ECIA敏感;高应答者）和LEW. B3（RT 1 n/n; ECIA耐药;低至中等应答者）交配的F2子代中，确定了控制ECIA敏感性的基因分离和对天然小牛II型胶原蛋白的免疫应答水平。RT 1 n/n F2子代显示出对ECIA的抗性、对II型胶原蛋白的低皮试反应性和中等水平的IgG抗胶原蛋白抗体（-log 2为6.2 ± 2.6;平均值± SD，n= 10）。RT 1u/u和RT 1u/u F2子代对ECIA易感，并且通过皮肤试验和IgG抗体滴度（-log 2为12.1 ± 1.3，平均值± SD，n= 26）对II型胶原蛋白具有高应答。尽管所有发生关节炎的大鼠对II型胶原也有高反应，但一组未成熟的F2后代RT 1u/u和RT 1u/n在没有可检测到的关节炎的情况下显示出高抗胶原免疫反应。数据表明，与RT1.A相关的基因控制了WF和LEW.B3大鼠对ECIA的易感性和对天然小牛II型胶原蛋白的至少部分免疫应答。
The segregation of genes controlling ECIA susceptibility and the level of immune response to native calf type II collagen were determined in the F2 progeny of matings between WF (RTIu/u; ECIA‐susceptible; high responders) and LEW.B3 (RT1n/n; ECIA‐resistant; low to intermediate responders). RT1n/n F2 progeny showed resistance to ECIA, low skin test reactivity to type II collagen and intermediate levels of IgG anti‐collagen antibodies (‐log2 of 6.2 ± 2.6; mean ± SD, n= 10). RT1u/u and RT1u/u F2 progeny were susceptible to ECIA and were high responders to type II collagen by skin testing and IgG antibody titres (‐log2 of 12.1 ± 1.3, mean ± SD, n= 26). Although all rats that developed arthritis were also high responders to type II collagen one group of immature F2 progeny, RT1u/u and RT1u/n, showed high anti‐collagen immune responses in the absence of detectable arthritis. The data indicate that genes linked to RT1.A control susceptibility to ECIA and at least part of the immune response to native calf type II collagen in WF and LEW.B3 rats.