Expression of interleukin-9 and its upstream stimulating factors in rats with ischemic stroke
Expression of interleukin-9 and its upstream stimulating factors in rats with ischemic stroke
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缺血性脑卒中大鼠白细胞介素9及其上游刺激因子的表达
DOI：
10.1007/s10072-015-2096-2
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发表时间：
2015-06-01
影响因子：
3.3
通讯作者：
Lu, Zhengqi
中科院分区：
文献类型：
--
作者：
Lin, Yinyao;Zhang, Lei;Lu, Zhengqi
目的探讨大鼠大脑中动脉闭塞后IL-9及其相关细胞因子的时间表达。在大鼠短暂局灶性缺血后，检测缺血脑和血中IL-9及其相关细胞因子的变化。与假手术组比较，实验组大脑中动脉闭塞后IL-4、TGF-β、PU.1、IRF4、OX40、NIK、RelB-p52、IL-9水平均显著升高。结果表明，IL-9及其上游刺激因子在实验性脑卒中中表达增加，其是否发挥作用或仅为继发性变化有待进一步研究。
To investigate the temporal expressions of IL-9 and its related cytokines after middle cerebral artery occlusion in rats. IL-9 and its related cytokines in ischemia brain and blood were tested after rats were subjected to transient focal ischemia. Comparing with sham-operated group, the levels of IL-4, TGF-β, PU.1, IRF4, OX40, NIK, RelB-p52 and IL-9 in experimental groups were significantly higher after middle cerebral artery occlusion. The results showed that expressions of IL-9 and its upstream stimulating factors increased in experimental stroke, and whether they play a role or just a secondary change is awaiting further research.