Antiproliferative ent-kaurane diterpenoids isolated from the roots of Zea mays L.
Antiproliferative ent-kaurane diterpenoids isolated from the roots of Zea mays L.
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DOI：
10.1016/j.fitote.2019.02.008
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发表时间：
2019-04-01
期刊：
影响因子：
3.4
通讯作者：
Xu, Yongnan
中科院分区：
文献类型：
--
作者：
Wang, Andong;Fan, Yanhua;Xu, Yongnan
从玉米根中分离到4个新的正戊烷二萜玉米A-D（1-4）和14个已知化合物。化合物7、15、16为首次从该属植物中分离得到。通过对新化合物的NMR和HR-ESI-MS谱的广泛分析确定了它们的平面结构，并根据比旋光度与计算的ECD谱建立了它们的绝对构型。化合物2、6和18对5种人癌细胞（A549、MDA-MB-231、SK-Hep-1、SNU638、HCT116）具有显著的抗增殖作用，IC50值在1.99 +/- 0.41 ~ 15.18 +/- 1.17 μ M之间。
Four new ent-kaurane diterpenoid maizediterpenes A-D (1-4), along with fourteen known compounds were isolated from the roots of Zea mays (maize). Compounds 7, 15, 16 were isolated from this genus for the first time. The planar structures of the new compounds were determined by extensive analysis of their NMR and HR-ESI-MS spectra, and the absolute configurations were established on the basis of specific rotation in association with calculated ECD spectra. Compounds 2, 6 and 18 showed significant antiproliferative effects against five human cancer cell lines (A549, MDA-MB-231, SK-Hep-1, SNU638, HCT116) with IC50 values ranging from 1.99 +/- 0.41 mu M to 15.18 +/- 1.17 mu M.