Large lungs after childhood asthma: a consequence of enlarged airspaces.
Large lungs after childhood asthma: a consequence of enlarged airspaces.
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儿童哮喘后肺部变大：气腔扩大的结果。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
H. Colebatch
中科院分区：
文献类型：
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作者：
I. Greaves;H. Colebatch
在18例哮喘患者中研究了哮喘对肺容量的长期影响，这些患者在气道阻塞缓解期间; 10例在儿童期（8岁之前）和8例在18岁之后发生哮喘。儿童期开始哮喘的受试者平均肺容量（TLC）增加;成年期发作的哮喘患者平均肺容量正常。指数分析的静态压力-容量曲线在这些受试者中显示，儿童期发作的哮喘患者的肺的扩张性增加，而成人发作的哮喘患者的肺的扩张性正常。在另外10名过去患有哮喘和肺活量增加的成年人中，所有人都在儿童时期患有哮喘，肺部扩张性增加，TLC增加。个体内扩张性增加和TLC增加密切相关。在哺乳动物肺中证实的扩张性和外周空气空间大小之间的密切关系表明，儿童哮喘可能会增加TLC和扩张性，因为外周空气空间的大小增加。
The long-term effects of asthma on lung volume were investigated in 18 asthmatic patients during periods of remission from airway obstruction; ten had developed asthma in childhood (before 8 years of age) and eight after the age of 18 years. Subjects whose asthma began in childhood had an increased total lung capacity (TLC) on average; adult-onset asthmatics had normal mean lung volumes. Exponential analysis of static pressure-volume curves in these subjects showed that the childhood-onset asthmatics had lungs of increased distensibility, while adult-onset asthmatics had lungs of normal distensibility. In a further ten adults selected for having had asthma in the past and an increased vital capacity, all had developed asthma in childhood, had lungs of increased distensibility and an increased TLC. Increased distensibility and an increased TLC were closely associated within individuals. The close relationship between distensibility and the size of peripheral air spaces demonstrated in mammalian lungs, suggests that asthma in childhood may increase TLC and distensibility because of an increase in the size of peripheral airspaces.