Impact of gestational diabetes on the risk of diabetes following pregnancy among Chinese and South Asian women
Impact of gestational diabetes on the risk of diabetes following pregnancy among Chinese and South Asian women
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DOI：
10.1007/s00125-012-2549-6
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发表时间：
2012-08-01
期刊：
影响因子：
8.2
通讯作者：
Shah, B. R.
中科院分区：
文献类型：
--
作者：
Mukerji, G.;Chiu, M.;Shah, B. R.
种族和妊娠期糖尿病（GDM）都是2型糖尿病发生的危险因素。然而，种族是否改变GDM对糖尿病风险的影响尚不确定。我们的目的是确定与白色妇女相比，中国和南亚妇女妊娠合并或不合并GDM后患糖尿病的风险。使用医疗保健数据库，确定了安大略1995年1月至2008年6月期间所有1，050，108名年龄在20-49岁的活产妇女。对这些妇女进行长达15年的糖尿病诊断随访，中国、南亚和白色妇女GDM的年龄标准化患病率分别为4.1%、7.1%和2.9%。在中位随访时间7.6年时，确诊糖尿病的累积发病率在中国有和无GDM女性中分别为16.5%和1.8%，在南亚有和无GDM女性中分别为31.8%和3.6%，在白色有和无GDM女性中分别为25.7%和1.8%。妊娠期糖尿病的存在使白色妇女怀孕后患糖尿病的风险增加了13倍以上，但在中国和南亚妇女中仅增加了9 - 10倍，尽管三分之一的南亚妇女在产后8年内被诊断出患有糖尿病，但中国和南亚妇女中妊娠期糖尿病对糖尿病风险的增加影响不如白色妇女。
Ethnicity and gestational diabetes mellitus (GDM) are both risk factors for the development of type 2 diabetes. However, it is uncertain whether ethnicity modifies the effect of GDM on diabetes risk. We aimed to determine the risk of diabetes following pregnancy with and without GDM for Chinese and South Asian women compared with white women.Using healthcare databases, all 1,050,108 women aged 20-49 with live births between January 1995 and June 2008 in Ontario were identified. They were followed for up to 15 years for the diagnosis of diabetes.The age-standardised prevalences of GDM were 4.1%, 7.1% and 2.9% for Chinese, South Asian and white women, respectively. The cumulative incidence of diagnosed diabetes at the median follow-up time of 7.6 years was 16.5% and 1.8% for Chinese women with and without GDM, 31.8% and 3.6% for South Asian women with and without GDM, and 25.7% and 1.8% for white women with and without GDM. The presence of GDM conferred an increase in the risk for diabetes after pregnancy of more than 13-fold in white women, but only a nine- to tenfold increase among Chinese and South Asian women.Although one-third of South Asian women with GDM were diagnosed with diabetes within 8 years postpartum, the incremental impact of GDM on diabetes risk was not as strong among Chinese and South Asian women as it was among white women.