Soluble form of Fas and Fas ligand in serum and bronchoalveolar lavage fluid on individuals infected with human T-lymphotropic virus type 1
Soluble form of Fas and Fas ligand in serum and bronchoalveolar lavage fluid on individuals infected with human T-lymphotropic virus type 1
复制标题
DOI：
10.1016/j.rmed.2003.09.015
复制
发表时间：
2004-03-01
影响因子：
4.3
通讯作者：
Kohno, S
中科院分区：
文献类型：
--
作者：
Sakamoto, N;Mukae, H;Kohno, S
人类T淋巴细胞性病毒1型(HTLV-1)携带者已知会发生以T淋巴细胞性肺泡炎为特征的肺部并发症。本研究旨在探讨无症状HTLV-1携带者肺组织中可溶性Fas(SFas)和sFas配体(SFasL)的表达及其意义。我们检测了16例血清无症状HTLV-1携带者和32例健康体检者血清和支气管肺泡灌洗液(BALF)中sFas和sFasL水平。HTLV-1携带者血清sFas和sFasL水平均显著高于对照组。在BALE中，无症状携带者的淋巴细胞百分率、CD4+T细胞百分率和sFasL水平也显著高于对照组，而sFas水平在两组间无显著差异。BALF中sFasL水平与血清sFasL水平及BALE中CD4+T细胞百分率呈显著正相关。提示无症状HTLV-1携带者肺组织中sFasL水平的升高与CD4+T细胞的聚集有关，感染HTLV-1的T细胞对凋亡的抵抗和sFasL的过度产生可能通过下调Fas-FasL介导的细胞凋亡而导致T淋巴细胞性肺泡炎。(C)2003爱思唯尔有限公司。保留所有权利。
Human T-tymphotropic virus type 1 (HTLV-1) carriers are known to develop pulmonary complications characterized by T-lymphocytic alveolitis. The aim of this study was to determine the profile and role of soluble Fas (sFas) and sFas ligand (sFasL) in the lung of asymptomatic HTLV-1 carriers. We measured sFas and sFasL levels in serum and bronchoalveolar lavage fluid (BALF) of 16 seropositive asymptomatic HTLV-1 carriers and 32 healthy subjects. The serum levels of both sFas and sFasL were significantly higher in HTLV-1 carriers than in the control. In BALE the percentage of lymphocytes and CD4 positive T-cells, and the levels of sFasL were also significantly higher in asymptomatic carriers than the control, but there were no significant differences in sFas Levels between the two groups. There was a significant correlation between BALF sFasL levels and serum sFasL levels and percentage of CD4 positive T-cells in BALE Our results suggest that the increased Levels of sFasL in the lung of asymptomatic HTLV-1 carriers are associated with accumulation of CD4 positive T-cells, and that resistance to apoptosis in HTLV-1 infected T-cells and overproduction of sFasL could contribute to T-lymphocytic alveolitis by down-regulating Fas-FasL mediated apoptosis. (C) 2003 Elsevier Ltd. All rights reserved.