Recent Developments in the Deoxyfluorination of Alcohols and Phenols: New Reagents, Mechanistic Insights, and Applications
Recent Developments in the Deoxyfluorination of Alcohols and Phenols: New Reagents, Mechanistic Insights, and Applications
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醇和酚脱氧氟化的最新进展：新试剂、机理见解和应用
DOI：
10.1055/s-0036-1590881
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发表时间：
2017-11-01
影响因子：
2.6
通讯作者：
Hunter, Luke
中科院分区：
文献类型：
--
作者：
Hu, Wen-Li;Hu, Xiang-Guo;Hunter, Luke
本文简要介绍了2011 - 2017年酚类和醇类脱氧氟化新试剂和新方法的研究进展。讨论了对这些过程的机理理解的重要进展。通过案例研究，包括18f放射性合成和制备外来多氟化合物的例子，突出了脱氧氟化化学对合成有价值的目标分子的持续重要性。1引言2新型脱氧氟化试剂3“传统”脱氧氟化试剂的新应用4结论与未来方向
Abstract This short review describes the development of new reagents and methods for the deoxyfluorination of phenols and alcohols during the period of 2011 to 2017. Important advances in the mechanistic understanding of these processes are discussed. The continuing importance of deoxyfluorination chemistry for the synthesis of valuable target molecules is highlighted through case studies including examples of 18F-radiosynthesis and the preparation of exotic multifluorinated compounds. 1 Introduction 2 New Deoxyfluorination Reagents 3 Novel Applications of ‘Legacy’ Deoxyfluorinating Reagents 4 Conclusions and Future Directions