GM3 GANGLIOSIDE INDUCES HAMSTER FIBROBLAST GROWTH-INHIBITION IN CHEMICALLY-DEFINED MEDIUM - GANGLIOSIDE MAY REGULATE GROWTH-FACTOR RECEPTOR FUNCTION
GM3 GANGLIOSIDE INDUCES HAMSTER FIBROBLAST GROWTH-INHIBITION IN CHEMICALLY-DEFINED MEDIUM - GANGLIOSIDE MAY REGULATE GROWTH-FACTOR RECEPTOR FUNCTION
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DOI：
10.1016/0006-291x(82)91769-7
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发表时间：
1982-01-01
影响因子：
3.1
通讯作者：
HAKOMORI, S
中科院分区：
文献类型：
--
作者：
BREMER, EG;HAKOMORI, S
GM3 or GM1 ganglioside exogenously added in chemically-defined medium incorporate equally into cells. However, only GM3 showed a significant growth inhibition to hamster fibroblasts. The GM3-fed cells became refractory to growth stimulation by fibroblast growth factor (FGF) in chemically-defined media. Radiolabeled FGF accumulated on GM3-fed cells, but not on GM1-fed cells. Both GM3 nd GM1 did not directly interact with FGF. GM3 may regulate the function of the receptors for growth hormones.
