Does the possession of virulence factor genes mean that those genes will be active?
Does the possession of virulence factor genes mean that those genes will be active?
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DOI：
10.2166/wh.2009.066
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发表时间：
2009-01-01
影响因子：
2.3
通讯作者：
Edberg, Stephen C.
中科院分区：
文献类型：
--
作者：
Edberg, Stephen C.
宿主可以与我们摄入的微生物建立许多关系。对于绝大多数微生物来说，它们与人类宿主的联系是短暂的。它们要么被胃酸或胆汁破坏，要么甚至不能在胃肠道中建立临时居留权。在生命的早期，身体的粘膜表面建立了常驻的且通常稳定的正常植物群。这些正常的植物群微生物，其中大多数是细菌，具有针对消化道特定区域的特定受体。如果外来微生物能够在体内定居，那么它就可能暂时或永久地成为正常植物群的一部分。然而，为了产生疾病，它必须拥有一套额外的毒力因子。虽然其中一些是已知的，但许多是未知的。已知的那些包括酶，例如蛋白酶、脂肪酶和酯酶。因此，VFAR可能与人类疾病无关，其存在或不存在没有公共卫生意义。
There are a number of relationships the host can establish with the microbes we ingest. For the vast majority of microbes, they have a short-lived liaison with the human host. Either they are destroyed by the stomach acid or bile, or can not establish even a temporary residency in the gastrointestinal tract. Early in life the mucosal surfaces of the body establishes a resident, and generally stable, normal flora. These normal flora microbes, the majority of which are bacteria, have specific receptors for specific areas of the alimentary tract. If the foreign microbe can establish residency, it then may transiently or permanently become part of the normal flora. However, in order to produce disease, it must possess an additional set of virulence factors. While some of these are known, many are not. Those that are known include enzymes, such as protease, lipase, and esterase. Accordingly, VFAR may not be associated with human disease and its presence or absence has no public health meaning.