Pulse pressure predicts cardiovascular risk in patients with type 2 diabetes mellitus
Pulse pressure predicts cardiovascular risk in patients with type 2 diabetes mellitus
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DOI：
10.1016/j.amjhyper.2005.05.009
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发表时间：
2005-11-01
影响因子：
3.2
通讯作者：
Currie, CJ
中科院分区：
文献类型：
--
作者：
Cockcroft, JR;Wilkinson, IB;Currie, CJ
背景：脉压（PP）是动脉僵硬度的标志，在老年人中比收缩压（SBP）或舒张压（DBP）更能预测冠心病（CHD）风险。对于心血管疾病风险增加的 2 型糖尿病患者是否也是如此，尚不清楚。方法：从卡迪夫糖尿病数据库中提取了 2911 名 2 型糖尿病患者的血压 (BP)、其他危险因素和心血管事件相关数据。在校正年龄、性别、胆固醇和吸烟状况后，使用 Logistic 回归评估血压成分与 CHD、脑血管 (CVD) 和外周血管 (PVD) 事件风险之间的关系。 结果：在 4 年随访期间，有 574 例 CHD、168 例 CVD 和 157 例 PVD 事件。 PP 和 SBP 与所有事件类型的风险均呈正相关，但 DBP 则不然。然而，PP 成为 CHD 事件的最佳预测因子，SBP 成为 CVD 和 PVD 事件的最佳预测因子。总胆固醇和高密度脂蛋白胆固醇是年龄之后与 PP 相关的最重要的变量。结论：总之，对于 2 型糖尿病患者，PP 比 SBP 更能预测 CHD 事件，但对于 CVD 和 PVD 则相反。 Ain J Hypertens 2005;18: 1463-1467 (D 2005 American Journal of Hypertension, Ltd.
Background: Pulse pressure (PP), a marker of arterial stiffness, is a better predictor of coronary heart disease (CHD) risk than systolic blood pressure (SBP) or diastolic blood pressure (DBP) in older adults. Whether this is also true in subjects with type 2 diabetes, who are at increased risk for cardiovascular disease, is unknown.Methods: Data on 2911 type 2 diabetic subjects relating to blood pressure (BP), other risk factors, and cardiovascular events were abstracted from The Cardiff Diabetes Database. Logistic regression was used to assess the relationship among BP components and the risk of CHD, cerebrovascular (CVD), and peripheral vascular (PVD) events after correction for age, gender, cholesterol, and smoking status.Results: In the 4-year follow-up period there were 574 CHD, 168 CVD, and 157 PVD events. Both PP and SBP, but not DBP, were positively associated with the risk of all event types. However, PP emerged as the best predictor of CHD events, and SBP as the best predictor of CVD and PVD events. Total and HDL-cholesterol were the most important variables associated with PP after age.Conclusions: In summary, PP is abetter predictor of CHD events than SBP in persons with type 2 diabetes, but the converse is true for CVD and PVD. Ain J Hypertens 2005;18: 1463-1467 (D 2005 American Journal of Hypertension, Ltd.