Curcumin-loaded polymeric nanoparticles for enhanced anti-colorectal cancer applications
Curcumin-loaded polymeric nanoparticles for enhanced anti-colorectal cancer applications
复制标题
DOI：
10.1177/0885328215594479
复制
发表时间：
2015-11-01
影响因子：
2.9
通讯作者：
Chiang, Been-Huang
中科院分区：
文献类型：
--
作者：
Udompornmongkol, Panisa;Chiang, Been-Huang
本研究的目的是制备聚合物纳米颗粒作为药物载体，用于包封具有增强的抗结直肠癌应用的姜黄素。以天然多糖--壳聚糖和阿拉伯胶为原料，采用乳化溶剂扩散法制备纳米粒。通过傅里叶变换红外光谱和差示扫描量热仪证实了姜黄素纳米粒的形成。结果表明，姜黄素包封在电压为+48 mV、粒径为136 nm的载体中，包封率高达95%。基于体外释放研究，我们推断姜黄素纳米颗粒可以耐受由于胃液或小肠酶引起的水解，因此，它应该基本上完整地到达结肠。此外，由于细胞吸收更大，姜黄素纳米颗粒比游离姜黄素具有更高的抗结直肠癌特性。因此，我们的结论是，姜黄素被成功地封装在壳聚糖-阿拉伯胶纳米颗粒具有上级抗结直肠癌活性。
The purpose of the present study was to fabricate polymeric nanoparticles as drug carriers for encapsulated curcumin with enhanced anti-colorectal cancer applications. Nanoparticles were formulated from chitosan and gum arabic, natural polysaccharides, via an emulsification solvent diffusion method. The formation of curcumin nanoparticles was confirmed by Fourier transform infrared spectroscopy and differential scanning calorimeter. The results show that curcumin was entrapped in carriers with +48mV, 136 nm size, and high encapsulation efficiency (95%). Based on an in vitro release study, we inferred that curcumin nanoparticles could tolerate hydrolysis due to gastric juice or small intestinal enzymes, and therefore, it should reach the colon largely intact. In addition, curcumin nanoparticles had higher anti-colorectal cancer properties than free curcumin due to greater cellular uptake. Therefore, we concluded that curcumin was successfully encapsulated in chitosan-gum arabic nanoparticles with superior anti-colorectal cancer activity.