Synthesis of water-soluble and functionalized nanoparticles by silica coating
Synthesis of water-soluble and functionalized nanoparticles by silica coating
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DOI：
10.1021/cm071368z
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发表时间：
2007-10-16
影响因子：
8.6
通讯作者：
Ying, Jackie Y.
中科院分区：
文献类型：
--
作者：
Jana, Nikhil R.;Earhart, Christopher;Ying, Jackie Y.
在有机溶剂中合成高质量近单分散金属、金属氧化物和量子点纳米颗粒的方法已经很成熟，但由于缺乏水溶性和定制的表面化学，它们的应用受到限制。在这项工作中，我们报告了各种疏水纳米颗粒（包括 Au、Ag、Fe3O4 和 ZnS-CdSe）的二氧化硅涂层程序，以衍生出水溶性和功能化纳米颗粒。我们开发了一种使用市售硅烷在甲苯中涂覆二氧化硅的方法。该方法适用于尺寸范围为2-20 um的疏水性纳米颗粒。二氧化硅涂层纳米粒子的尺寸为 10-30 nm，水溶性，缓冲液稳定，并且具有正或负表面电荷，具体取决于表面官能团和溶液 pH 值。包覆颗粒的外表面上具有伯胺基团，并进一步用生物素和抗体进行功能化。
Synthetic methods for high-quality near-monodispersed nanoparticles of metals, metal oxides, and quantum dots in organic solvents are well-developed, but their applications are restricted due to the lack of water solubility and tailored surface chemistry. In this work, we report the silica-coating procedure for various hydrophobic nanoparticles, including Au, Ag, Fe3O4, and ZnS-CdSe to derive water-soluble and functionalized nanoparticles. We have developed a silica-coating method in toluene using commercially available silanes. This approach is applicable to hydrophobic nanoparticles in the size range of 2-20 urn. Silica-coated nanoparticles are 10-30 nm in size, water-soluble, buffer-stable, and have a positive or negative surface charge depending on the surface functional group and solution pH. The coated particles have primary amine groups on the outer surface and are further functionalized with biotin and antibody.