Highly enantioselective Michael addition of malononitrile to α,β-unsaturated ketones
Highly enantioselective Michael addition of malononitrile to α,β-unsaturated ketones
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DOI：
10.1039/b713129a
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发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Deng, Jingen
中科院分区：
文献类型：
--
作者：
Li, Xuefeng;Cun, Lingfeng;Deng, Jingen
研究了丙二腈与无环和环状α，β-不饱和酮的高不对称Michael加成反应。由奎尼丁衍生的伯胺催化的Michael反应顺利进行，并提供了具有优异的对映选择性（83- 97%ee）的所需加合物。
The highly enantioselective Michael addition of malononitrile to acyclic and cyclic alpha,beta-unsaturated ketones has been developed. The Michael reaction catalyzed by a primary amine derived from quinidine proceeded smoothly and provided the desired adducts with excellent enantioselectivities (83-97% ee).