Drug-Induced Acute Kidney Injury A Focus on Risk Assessment for Prevention
Drug-Induced Acute Kidney Injury A Focus on Risk Assessment for Prevention
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DOI：
10.1016/j.ccc.2015.06.005
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发表时间：
2015-10-01
影响因子：
4.3
通讯作者：
Goldstein, Stuart L.
中科院分区：
文献类型：
--
作者：
Kane-Gill, Sandra L.;Goldstein, Stuart L.
药物是继败血症和低血压之后危重患者急性肾损伤（阿基）的第三至第五大原因。已经确定了发生阿基的易感性和暴露，有些是可以改变的，可以预防阿基或减轻阿基的严重程度。使用药物治疗预防阿基已被尝试，但在人类研究中几乎没有成功，因此我们必须依靠风险评估策略进行预防。本文旨在综述药物性阿基的危险因素、风险评估策略、预防和管理，重点是风险评估。
Drugs are the third to fifth leading cause of acute kidney injury (AKI) in critically ill patients following sepsis and hypotension. Susceptibilities and exposures for development of AKI have been identified, and some are modifiable allowing for the possibility of AKI prevention or mitigation of AKI severity. Using drug therapies for prevention of AKI has been attempted but with little success in human studies, so we must rely on risk-assessment strategies for prevention. The purpose of this article is to review the risk factors, risk-assessment strategies, prevention, and management of drug-induced AKI with emphasis on risk assessment.